04080nam 22007095 450 991040969270332120220615134919.03-030-44599-210.1007/978-3-030-44599-7(CKB)4100000011263817(MiAaPQ)EBC6207846(DE-He213)978-3-030-44599-7(PPN)248394843(EXLCZ)99410000001126381720200521d2020 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierNrf2 and its Modulation in Inflammation[electronic resource] /edited by Huai Deng1st ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (210 pages)Progress in Inflammation Research,0379-0363 ;853-030-44597-6 Includes bibliographical references.Chapter 1. Molecular mechanisms of Nrf2 in inflammation: Interactions between Nrf2 and inflammatory mediators -- Chapter 2. Nrf2 in immune responses during inflammation -- Chapter 3. Nrf2 and Nrf2-interacting network in respiratory inflammation and diseases -- Chapter 4. Nrf2 in the regulation of endothelial cell homeostasis during inflammation -- Chapter 5. The roles of Nrf2 in cardiovascular system and atherosclerosis -- Chapter 6. Nrf2 and inflammation-triggered carcinogenesis -- Chapter 7. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases -- Chapter 8. Modulators of Nrf2 Activation during Inflammation.Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation,respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.Progress in Inflammation Research,0379-0363 ;85ImmunologyCell physiologyGene expressionOxidative stressImmunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Cell Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L33010Gene Expressionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12010Oxidative Stresshttps://scigraph.springernature.com/ontologies/product-market-codes/L16070Expressió gènicathubProteïnesthubImmunitat cel·lularthubLlibres electrònicsthubImmunology.Cell physiology.Gene expression.Oxidative stress.Immunology.Cell Physiology.Gene Expression.Oxidative Stress.Expressió gènicaProteïnesImmunitat cel·lular572.8845Deng Huaiedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910409692703321Nrf2 and its Modulation in Inflammation2543884UNINA