05266nam 2201537z- 450 991040409140332120231214132836.03-03928-699-4(CKB)4100000011302224(oapen)https://directory.doabooks.org/handle/20.500.12854/43261(EXLCZ)99410000001130222420202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCirculating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer DisseminationMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (366 p.)3-03928-698-6 The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.Circulating Tumor CellsFOLFIRINOXimmunofluorescence imagingAR-V7circulating tumour cellschemoradioresistanceCTC-based treatment decisionsrVAR2immunophenotypingimmune systemCellSearch®flow cytometryclinical trialscirculating tumor DNAsynaptophysinstem cellscolorectal cancermelanomaCTC biologyplateletsARCTC capture technologycastration resistant prostate cancer (CRPC)PD-L1 expressionrovalpituzumab tesirineHMB-45thymidylate synthasectDNAtumor cell disseminationsolid cancersmetastasislocally advanced rectal cancermiRNAepithelial-to-mesenchymal transition (EMT)NSCLCtumor biomarkerstumor stem cellscirculating tumor cellsmajor histocompatibility complex class I (MHCI)bone marrowheterogeneitycerebrospinal liquid biopsyfishgliomain vivo flow cytometrycolorectal surgeryCellSearchsingle-cell analysisdisseminated tumor cellsEasyCount slidesmicrosatellite instabilitycirculating plasma cellscirculating leukemia cellsARV7SLUGandrogen receptormetastatic colorectal cancerleukocyte-derived extracellular vesiclesprostate cancer (PCa)neutrophilsliquid biopsyenzalutamideCD133enrichment and detection technologiesbiomarkersimmune checkpoint inhibitorsbiomarkerRAD23Bmicrobiomeintegrin B1ACCEPTembolismall-cell lung carcinomaEPISPOTmicrofluidicsearly breast cancercirculating tumor cells (CTC)tumor-initiating cells (TICs)immunomodulationxenograft modelsCTC-derived xenograftsmalariacirculating tumor cells (CTCs)clinical utilityexosomesliquid surgeryctRNACTCsepithelial-mesenchymal transitiontargeted therapyhematological cellsgene expression analysishepatocellular carcinoma (HCC)breast cancerEpCAM enrichmentprostate cancerCTCabirateronefibronectinCTC-derived ex vivo modelsCTMatchromogranin ACTMexosomeAlix-Panabieres Catherineauth1296959BOOK9910404091403321Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination3024332UNINA