05385nam 2201585z- 450 9910404091403321202102113-03928-699-4(CKB)4100000011302224(oapen)https://directory.doabooks.org/handle/20.500.12854/43261(oapen)doab43261(EXLCZ)99410000001130222420202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCirculating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer DisseminationMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (366 p.)3-03928-698-6 The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.Circulating Tumor CellsMedicine and NursingbicsscabirateroneACCEPTandrogen receptorARAR-V7ARV7biomarkerbiomarkersbone marrowbreast cancercastration resistant prostate cancer (CRPC)CD133CellSearchCellSearch®cerebrospinal liquid biopsychemoradioresistancechromogranin Acirculating leukemia cellscirculating plasma cellscirculating tumor cellscirculating tumor cells (CTC)circulating tumor cells (CTCs)circulating tumor DNAcirculating tumour cellsclinical trialsclinical utilitycolorectal cancercolorectal surgeryCTCCTC biologyCTC capture technologyCTC-based treatment decisionsCTC-derived ex vivo modelsCTC-derived xenograftsCTCsctDNACTMCTMatctRNAdisseminated tumor cellsearly breast cancerEasyCount slidesembolienrichment and detection technologiesenzalutamideEpCAM enrichmentEPISPOTepithelial-mesenchymal transitionepithelial-to-mesenchymal transition (EMT)exosomeexosomesfibronectinfishflow cytometryFOLFIRINOXgene expression analysisgliomahematological cellshepatocellular carcinoma (HCC)heterogeneityHMB-45immune checkpoint inhibitorsimmune systemimmunofluorescence imagingimmunomodulationimmunophenotypingin vivo flow cytometryintegrin B1leukocyte-derived extracellular vesiclesliquid biopsyliquid surgerylocally advanced rectal cancermajor histocompatibility complex class I (MHCI)malariamelanomametastasismetastatic colorectal cancermicrobiomemicrofluidicsmicrosatellite instabilitymiRNAn/aneutrophilsNSCLCPD-L1 expressionplateletsprostate cancerprostate cancer (PCa)RAD23Brovalpituzumab tesirinerVAR2single-cell analysisSLUGsmall-cell lung carcinomasolid cancersstem cellssynaptophysintargeted therapythymidylate synthasetumor biomarkerstumor cell disseminationtumor stem cellstumor-initiating cells (TICs)xenograft modelsMedicine and NursingAlix-Panabieres Catherineauth1296959BOOK9910404091403321Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination3024332UNINA