04459nam 2201201z- 450 991040408760332120231214133611.03-03928-783-4(CKB)4100000011302262(oapen)https://directory.doabooks.org/handle/20.500.12854/58616(EXLCZ)99410000001130226220202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRoles and Functions of ROS and RNS in Cellular Physiology and PathologyMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (230 p.)3-03928-782-6 Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and reactive nitrogen species (ROS and RNS) were identified as the key players initiating, mediating, and regulating the cellular and biochemical complexity of oxidative stress either as physiological (acting pro-hormetic) or as pathogenic (causing destructive vicious circle) process. The papers published in this particular Special Issue of the Cells demonstrate the impressive pathophysiological relevance of ROS and RNS in a range of contexts, including the relevance of second messengers of free radicals like 4-hydroxynonenal, allowing us to assume that even more detailed mechanisms of their positive and negative effects lie in wait, and should assist in better monitoring of the major modern diseases and the development of advanced integrative biomedicine treatments.toxicitytoll-like receptorsacroleinhydroxyapatite-based biomaterialsLC-MS/MSblood–brain barrierNADPH-oxidasehuman neuroblastoma SH-SY5Y cellsNRF2-NQO1 axisgranulocytesfree radicalsantioxidantplaque vulnerabilitybEnd.3relaxationCa2+keratinocytesoxidative metabolism of the cellslipid peroxidationintermittent hypoxiaosteoblast growthUV radiationROSbEnd5cyclopurinesNF?Bglucose deprivationantimicrobialendothelial cells4-hydroxynonenal (4-HNE)histamineglutamine deprivationoptical coherence tomographyantioxidantsDNA damageglutathioneNQO1 transcript variantsxeroderma pigmentosumcancer cellsVAS2870reactive oxygen species (ROS)TP53 mutationDNA and RNA polymerasesviabilityoxidative burstmacrophagesinflammationNrf2von Willebrand factorreactive oxygen speciesgrowth controlintracellular signalingMFN2nuclear factor erythroid 2–related factor 2fusion/fissionIMR-90calciumproliferationmitochondriapathophysiology of oxidative stressredox balance4-hydroxynonenalcannabidioloxidative homeostasisrs1800566neuronal cell deathheme-oxygenase-1vitaminscell signalingTRPM2 channelaortacancergrowthcancer regressionoxidative stressnucleotide excision repairZarkovic Nevenauth1287827BOOK9910404087603321Roles and Functions of ROS and RNS in Cellular Physiology and Pathology3020454UNINA