02214nam 2200493z- 450 9910619476303321202210261-920382-52-6(CKB)4100000011868316(oapen)https://directory.doabooks.org/handle/20.500.12854/93342(VLeBooks)9781920382520(oapen)93342(EXLCZ)99410000001186831620202210d2014 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDaar is water 'n reisigersblik op die Xhariepse gemeenskap in oorgang = There is water : a traveller's view of the Xhariepean community in transition /Lut Teck ; translation by Jeanne-Leanne SmitBloemfonteinUJ Press20141 electronic resource (108 p.)1-920382-51-8 This unique trilingual publication offers a traveller's view of the people of the Xhariep and their daily lives. The book results from a research project in the southern Free State, 'Multilingualism for Empowerment', that was undertaken with the financial assistance of the Province of Antwerp in Flanders, Belgium, and in collaboration with the University of Antwerp. The book entails a collection of journal entries, photographs, interview material and background information recorded by Lut Teck, a Flemish member of the research team, during her field work in the area.Diaries, letters & journalsbicsscDiaries, letters and journalsbicsscXhariep District Municipality (South Africa)Description and travelFree State (South Africa)Description and travellandscapessettingvoicescommunitiesXhariep DistrictXhariepeanmultilingualismDiaries, letters & journalsDiaries, letters and journals553.7Teck Lut1309486Smit Jeanne-Leanne1771914BOOK9910619476303321Daar is water4266903UNINA03942nam 2200901z- 450 9910404087203321202102113-03928-041-4(CKB)4100000011302266(oapen)https://directory.doabooks.org/handle/20.500.12854/53236(oapen)doab53236(oapen)53236(EXLCZ)99410000001130226620202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMetabolomics in Neurodegenerative DiseaseMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (184 p.)3-03928-040-6 The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health services. Tens of millions of people are indiscriminately affected by various dementias, which are rising at an alarming rate. There are no cures for many conditions, and it is clear that treatments applied as early as possible could greatly improve outcomes for patients. Therefore, new disease classification and diagnostic tools should be a key priority. Metabolomics represents a relatively new field of analytical science, which can be extremely useful in the early diagnosis of disease. The relatively unique feature of metabolites is that they sit at the intersection between the genetic background of an organism and its environment. Because many neurodegenerative diseases are not genetically inherited (instead having a range of known genetic risk factors and also a large number of unknown environmental triggers) the field of metabolomics offers great promise for the discovery of new, biologically, and clinically relevant biomarkers for neurodegenerative disorders. It is already bringing forward new knowledge in terms of the mechanisms of neurodegenerative disease.Biology, life sciencesbicssc?-synuclein aggregates13C-labeled succinate1H NMR6-OHDAage-related macular degenerationAlzheimer's diseasebile acidsbiomarkersC. eleganscerebral ischemiacerebral palsydementia with Lewy bodiesdirect mass spectrometrydrusenendothelin-1energy metabolismexcitotoxicityfatty acidfatty acid metabolismGC-MSglutamic acidimaging mass spectrometryLC-MSlipidomicsmalonatemass spectrometrymetabolic pathwaysmetabolismmetabolomicsmicro-dialysismidbrainmitochondrial dysfunctionmyo-inositoln/anatural productneurodegenerationParkinson's diseaseParkinson's disease dementiapathogenesisplasmaprodromal Parkinson's diseasereperfusionretinal pigment epitheliumStreptomyces venezuelaesubacute mild traumatic brain injurytargeted mass spectrometrytricarboxylic acid cycleBiology, life sciencesGreen Brianauth732791BOOK9910404087203321Metabolomics in Neurodegenerative Disease3032111UNINA