03401 am 2200565 n 450 991049568690332120240104030720.02-39061-040-4(CKB)4100000011945177(FrMaCLE)OB-pucl-6039(PPN)256383294(EXLCZ)99410000001194517720210603j|||||||| ||| 0enguu||||||m||||How Long is a Century?Late Minoan IIIB Pottery. Relative Chronology and Regional DifferencesCharlotte LangohrLouvain-la-NeuvePresses universitaires de Louvain20211 online resource (414 p.) 2-87558-636-X Covering approximately the century between 1300 and 1200 BC, the Late Minoan IIIB phase remains a blurred episode of Minoan civilisation. Archaeological data present a contradictory picture: on the one hand, they suggest a time of prosperity. with favourable conditions of subsistence and growth; on the other hand, there are signs of trouble illustrated by a series of abandonments of century-old occupied settlements. Did these processes take place simultaneously, in succession or were they punctual? Can we make sense of the various hale Minoan IIIB developments from a chronological perspective? How can a region-by region analysis inform us about the various island communities and their histories during the 13th century BC? The international workshop which the present volume reflects took place at the UCLouvainin Belgium on the 24th and 25th of October 2013. It specifically addressed these questions and focused on the gradual transformation of Cretan society throughout the 13th century BC by concentrating on a single aspect of its material culture: the pottery. It was our infention to bring together a number of ceramic experts in charge of the study of Late Minoan IIIB pottery deposits in a selection of Cretan sites. We wanted them to discuss, confront and contextualise their respective assemblages. The gathering was successful in many ways and not in the least because not only we managed to progress on a variety of thorny issues but it was also a real treat to assist in the thrilling exchanges between the inspiring personalities who compose the ’family’ of Minoan (and Mycenaean) pottery specialists.ArchaeologypotteryarchaeologyexcavationMinoan civilisationArchaeologypotteryarchaeologyexcavationMinoan civilisationBorgna Elisabetta455290Chatzi-Vallianou Despina1454449Cucuzza Nicola747436Cunningham Tim1454450Hallager Birgitta1454451Hatzaki Eleni777882K. Smith R. Angus1454452Kanta Athanasia459608Kontopodi Danae Z1454453Langohr Charlotte1309347Lucia D’Agata Anna1454454Panagiotaki Marina1454455Panagiotakis Nikos1454456Paschalidis Kostas1454457Rutter Jeremy B1454458FR-FrMaCLEBOOK9910495686903321How Long is a Century3656905UNINA06946nam 2202041z- 450 9910404087003321202102123-03928-639-0(CKB)4100000011302268(oapen)https://directory.doabooks.org/handle/20.500.12854/58186(oapen)doab58186(EXLCZ)99410000001130226820202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRenal Cell CarcinomaMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (500 p.)9783039286386 Renal cancer is a health problem of major concern worldwide. Although tyrosine kinase inhibitors and immune check-point blockade treatments, alone or in combination, are giving promising results, failures are quite frequent due to intratumor heterogeneity and to the acquisition of drug resistance. The spectrum of renal cell carcinoma subtypes is wide. Up to 70-80% of renal tumors are clear cell renal cell carcinomas, a clinically aggressive tumor subtype linked to VHL gene inactivation. Next in frequency, the papillary renal cell carcinoma category encompasses an intricate puzzle of classic and newly described entities with poorly defined limits, some of them pending definite clarification. Likewise, the chromophobe-oncocytoma duality, the so-called hybrid tumors and oncocytic neoplasms, remain to be well profiled. Finally, a growing list of very uncommon renal tumors linked to specific molecular signatures fulfill the current portrait of renal cell neoplasia. This Special Issue of Cancers regards RCC from very different perspectives, from the intimate basic mechanisms governing this disease to the clinical practice principles of their diagnoses and treatments. The interested reader will have the opportunity to contact with some of the most recent findings and will be updated with excellent reviews.Biology, life sciencesbicssc11) translocation renal cell carcinomaALKAMP-activated protein kinasesanaplastic lymphoma kinase rearrangementaurora Abiomarkercancer immunotherapycancer-specific survivalCDKN1A expressioncheckpoint inhibitorschromophobe renal cell carcinomachromosomal losschronic kidney diseasecircular RNAs in a clinico-genomic predictive modelclear cell renal cell carcinomaclear cell Renal Cell Carcinomacollecting duct carcinomacopy number alterationcopy number analysiscopy number losscurcumincytoreductive nephrectomydiagnostic and prognostic markersdrug sensitivityefficacyemerging entityEMT likeeosinophilic variantESCeverolimusEVI1experimental validation of circular RNAFISHFOXO3gene expressiongene signaturegenetic associationghrelinglutathione metabolismglutathione transferase omega 1glutathione transferase omega 2glycomarkersglycoproteomicsHOThyperosmolalityidentification of circular RNAsIL-1?IL-2IL13R?1IL4R?immune checkpoint inhibitorsimmune infiltrationimmunohistochemistryimmunotherapyinflammation markersintegrinsintratumour heterogeneityinvasionJAK2kidneykidney cancerlabel-freeLOTmetabolic reprogrammingmetabolomemetabolome profilingmetastasismetastatic ccRCCmicroRNAmiR-133bmiR-146a-5pmiR-155-5pMiT family translocation renal cell carcinomaMMP-9MMP10molecular genetic featuresMTA2mTORmTOR inhibitorsmutationN-glycomappingn/anephrectomynew entityNK cellsoncocytic renal tumoroverall survivalpale cellPapillary renal cell carcinoma (pRCC)patient survivalPBRM1PD-L1pentose phosphate pathwayPI3K/Akt/mTORpolybromo-1polymorphismPPPpractical approachpredictive factorspredictive rolepro-IL-1?prognosisprognostic factorsprogrammed death-ligand 1proliferationproteome profilingRaf/MEK/ERKRCCrecurrence free survivalrecurrence-free survivalrenal cancerrenal cellrenal cell cancerrenal cell carcinomareviewRNA sequencingsarcomatoidSMAD proteinssolute carrier proteinsstatinssurvivalsurvival predictiont(6targeted therapyTCA cycleTCGATFE3TFEBTFEB-amplified renal cell carcinomatoxicitytransforming growth factor betatumor adhesiontumor microenvironmenttumor migrationtumor slice culturetyrosine kinase inhibitorsunclassified renal cell carcinomaunclassified renal tumoruric acidurineVEGF inhibitorsvon Hippel-LindauXp11 translocation renal cell carcinomaBiology, life sciencesLópez José Iauth0BOOK9910404087003321Renal Cell Carcinoma2809988UNINA