06473nam 2201777z- 450 9910404086803321202102113-03928-747-8(CKB)4100000011302270(oapen)https://directory.doabooks.org/handle/20.500.12854/54359(oapen)doab54359(EXLCZ)99410000001130227020202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNatural Products and Drug DiscoveryMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (392 p.)3-03928-746-X Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.Biology, life sciencesbicssc2?4?-dihydroxy-6?-methoxy-3?5?-dimethylchalcone (DMC)ACE inhibitory peptideacetylated astragalosidesagingangiogenesisanti-inflammatory activityantihypertensiveantimicrobial agentsantimicrobial resistanceantinociceptiveantioxidant activityartemisininAstragalus boeticus L.Bacopa monnieribioactive peptidesbioactivities of natural productsbiotechnologyC-glycosideCa2+cancercardamonincardiovascular diseasecelastrolcerebellumchemical derivatizationchemosystematicschromatographycircular dichroismCleistocalyx operculatusCubacytokinescytotoxic activitycytotoxicity-guidedDasycladus vermicularisdementiadevil's clawdiabetesdiabetic neuropathydihydrochalconesDryopteris fragransEruca sativaESI-MS/MSFabaceaeFidelosideflavonoidflavonoidsFSEglucoerucinglucosinolatesGLUT4glutamategrowth inhibitory activityH2SHarpagophytum procumbensharpagosideHPLCHPLC-ESI-microTOF-Q-MS/MShuman colon cancer cell linesHumulus lupulushypertensionimmuno-regulation activityImperata cylindricainflammationisoflavonesisolation and quantificationketamineKv7 potassium channelsL6 cellLamialesLC-MSLeea indicaLeishmania mexicana mexicanamalariamarine peptidesmarine resourcesmass spectrometrymetabolomicsmethicillin-resistant Staphylococcus aureusmigrationmolecular networkmultivariate data analysisn/aNADPH oxidasesnatural productsneuropathic painNMRopioidOrobanchaceaeOrobanche s.l.oxidative stressPANC-1phenolic derivativesphenolicsphenylethanoid glycosidesphenylpropanoid glycosidesPhyllanthus chamacristoidesPhyllanthus orbicularisPhyscomitrella patenspPancreatic cancerprenylated phenolic compoundsproanthocyanidinsproliferationpsychosissecondary metabolitessesquiterpenoidssiphonous green algaespagyric tincturespectroscopic analysisstereochemistrysulfated coumarinssynergyT2DMterpenesterpenoidstraditional medicineTrifoliumTRPV1Trypanosoma brucei bruceizebrafishBiology, life sciencesAvato Pinarosaauth1297601BOOK9910404086803321Natural Products and Drug Discovery3024600UNINA