03299nam 2200877z- 450 9910404084303321202102113-03928-255-7(CKB)4100000011302295(oapen)https://directory.doabooks.org/handle/20.500.12854/50093(oapen)doab50093(EXLCZ)99410000001130229520202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIn-Cell NMR Spectroscopy: Biomolecular Structure and FunctionMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (152 p.)3-03928-254-9 This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.]In-Cell NMR SpectroscopyBiology, life sciencesbicssc2D INADEQUATEAdenylate kinaseantimicrobial peptidecross-correlated relaxationcrystalline and amorphous starchDihydrofolate reductaseDNADNPdrug discoveryenzyme activityenzyme kineticsin-cell NMRin-situ NMRintrinsically disordered proteinslipid membranelive cellmagic-angle spinningmammalian cellsMARK2 phosphorylationmRNANMR spectroscopynon-uniform sampling 2paramagnetic effectspost-translational modificationsprotein dynamicsprotein interactionsprotein modificationprotein NMRprotein structureprotein structure determination 1protein structure-functionreviewRibosomerRNAsolid-state NMRspectrum reconstruction 3structural calculation 4structure functiontarget engagementTauThioredoxinThymidylate synthasetime-resolved NMRwhole cell NMRBiology, life sciencesBurz David Sauth1278676Shekhtman AlexanderauthBOOK9910404084303321In-Cell NMR Spectroscopy: Biomolecular Structure and Function3013715UNINA