03549nam 2201129z- 450 9910404077903321202102113-03928-918-7(CKB)4100000011302359(oapen)https://directory.doabooks.org/handle/20.500.12854/55413(oapen)doab55413(EXLCZ)99410000001130235920202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierOrgans-on-chipsMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (262 p.)3-03928-917-9 Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.History of engineering and technologybicssc3D cell culture3D cell culture systemangiogenesisbarrier permeabilitybeating forcebio-mechanical propertybiomechanicsbiomimetic oxidationcardiac 3D tissuecellcell culturecompressiondrug absorptiondrug efficacydrug hepatotoxicitydrug metabolismendothelial cell activationepithelial-endothelial interfacefluoroelastomerfunctional neuron imaginghigh-throughput screeninghuman induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM)image-based screeningintegrated pumpischemia/reperfusion injurylattice light-sheet microscopyliver-on-a-chiplung epithelial cellmechanical cuemembranesMEMSmicrofabricationmicrofluidic devicemicrofluidicsmulti-culturen/ananogroovesneuronal cell networksneuronal cellsneuronal guidanceorgan-on-a-chiporgan-on-a-chip (OOC)organ-on-chiporgan-on-chipsorganoidorgans-on-chipsparacellular/transcellular transportpassive deliveryPDMSSH-SY5Y cellsshear flowshear stresssiliconspheroid arraystrainstressstretchsurfactant proteinsyringe pumpthrombolysistissue engineeringtrans-epithelial electrical resistancevacuum chuckvascularizationvascularized tumor modelvessel branchingHistory of engineering and technologyTung Yi-Chungauth1290543Torisawa Yu-sukeauthBOOK9910404077903321Organs-on-chips3021527UNINA