04874nam 22006495 450 991037391910332120250609111005.0981-13-8719-210.1007/978-981-13-8719-7(CKB)4100000009837033(DE-He213)978-981-13-8719-7(MiAaPQ)EBC5975959(PPN)258059257(MiAaPQ)EBC5975518(EXLCZ)99410000000983703320191109d2019 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierProtein Allostery in Drug Discovery /edited by Jian Zhang, Ruth Nussinov1st ed. 2019.Singapore :Springer Singapore :Imprint: Springer,2019.1 online resource (XII, 384 p. 103 illus., 82 illus. in color.)Advances in Experimental Medicine and Biology,0065-2598 ;1163981-13-8718-4 Chapter 1. Allostery in Drug Development -- Chapter 2. Dynamic Protein Allosteric Regulation and Disease -- Chapter 3. Protein Allostery in Rational Drug Design -- Chapter 4. Progress in Allosteric Database -- Chapter 5. Correlation between Allosteric and Orthosteric Sites -- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators -- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins -- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands -- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network -- Chapter 10. GPCR Allosteric Modulator Discovery -- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors -- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs) -- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins -- Chapter 15. Engineering Allostery into Proteins.The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc. .Advances in Experimental Medicine and Biology,0065-2598 ;1163Pharmaceutical technologyProteinsBiomedical engineeringPharmaceutical Sciences/Technologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21010Protein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Protein Structurehttps://scigraph.springernature.com/ontologies/product-market-codes/L14050Biomedical Engineering/Biotechnologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B24000Tecnologia farmacèuticathubLlibres electrònicsthubPharmaceutical technology.Proteins.Biomedical engineering.Pharmaceutical Sciences/Technology.Protein Science.Protein Structure.Biomedical Engineering/Biotechnology.Tecnologia farmacèutica615.19Zhang Jianedthttp://id.loc.gov/vocabulary/relators/edtNussinov Ruthedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910373919103321Protein Allostery in Drug Discovery1965983UNINA03968nam 22005653 450 991102016100332120240512090318.09783527842612352784261697835278425993527842594(MiAaPQ)EBC31325953(Au-PeEL)EBL31325953(CKB)31993644200041(Exl-AI)31325953(Perlego)4410951(OCoLC)1433253811(EXLCZ)993199364420004120240512d2024 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierMagnesium-Based Energy Storage Materials and Systems1st ed.Newark :John Wiley & Sons, Incorporated,2024.©2024.1 online resource (179 pages)9783527352265 3527352260 Cover -- Title Page -- Copyright -- Contents -- Preface -- Acknowledgments -- Chapter 1 Overview -- 1.1 Introduction to Mg‐based Hydrogen and Electric Energy Storage Materials -- 1.2 Overview of Mg‐based Hydrogen Storage Materials and Systems -- 1.3 Overview of Mg‐ion Batteries -- Chapter 2 Hydrogen Absorption/Desorption in Mg‐based Materials and Their Applications -- 2.1 The Characterizations of Mg‐based Hydrogen Storage Materials -- 2.1.1 An Introduction to the Crystal Structure of Mg and MgH2 -- 2.1.2 Thermodynamic Mechanisms for the Hydrogen Absorption/Desorption of Mg/MgH2 -- 2.1.3 Kinetic Mechanisms for the Hydrogen Absorption/Desorption of Mg/MgH2 -- 2.2 Methods for Improving the Hydrogen Storage Performance of Mg‐based Materials -- 2.2.1 Alloying -- 2.2.2 Catalyzing -- 2.2.3 Nano‐structuring -- 2.2.4 Combining with Complex Hydrides -- 2.2.4.1 Combining with Metal Amides -- 2.2.4.2 Combining with Metal Boronhydrides or Alanates -- 2.3 Synthesis Technologies for Mg‐based Hydrogen Storage Materials -- 2.3.1 Preparation Methods of Mg‐based Alloys -- 2.3.1.1 Melting‐based Methods -- 2.3.1.2 Hydrogen Combustion Synthesis (HCS) -- 2.3.1.3 Mechanical Alloying, Compactions and Severe Plastic Deformation (SPD) Methods -- 2.3.1.4 Hydriding Chemical Vapor Deposition (HCVD) -- 2.3.2 Synthesis of Mg‐based Materials with Special Structure and Morphology -- 2.3.2.1 Synthesis of Core–Shell Structured Mg‐based MaterialsGenerated by AI.This book, 'Energy Storage Materials and Systems', authored by Jianxin Zou and colleagues, provides a comprehensive examination of energy storage materials, focusing on hydrogen and magnesium-based systems. It addresses the challenges and potential solutions for renewable energy storage, emphasizing the importance of materials like magnesium hydrides for high-density storage. The text delves into the mechanisms of hydrogen storage, including compressed, liquid, and solid-state methods, and explores the development of magnesium-ion batteries as a promising technology for sustainable energy storage. The book is intended for researchers, engineers, and professionals in the field of renewable energy and materials science, offering insights into the latest advancements and applications of these technologies.Generated by AI.Hydrogen as fuelGenerated by AIMagnesium electrodesGenerated by AIHydrogen as fuelMagnesium electrodes621.31242Zou Jianxin1836011NuLi Yanna1837900Hu Zhigang1837901Lin Xi1431320Zhang Qiuyu1837902MiAaPQMiAaPQMiAaPQBOOK9911020161003321Magnesium-Based Energy Storage Materials and Systems4416749UNINA