03935nam 22006615 450 991037391780332120220307162426.0981-13-7450-310.1007/978-981-13-7450-0(CKB)4100000009844673(DE-He213)978-981-13-7450-0(MiAaPQ)EBC5978023(PPN)260301914(EXLCZ)99410000000984467320191113d2019 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierActin Polymerization in Apicomplexan A Structural, Functional and Evolutionary Analysis /edited by Avinash Kale1st ed. 2019.Singapore :Springer Singapore :Imprint: Springer,20191 online resource (XI, 101 p. 11 illus. in color.)981-13-7449-X Includes bibliographical references.Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles -- Chapter 2. Introduction: Gliding Motility- The model and the mechanism -- Chapter 3. Actin: The central ubiquitous player in the phenomenon -- Chapter 4. Formin: The multidomain elongator of polymer -- Chapter 5. Profilin: The associates of Formin -- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis -- Chapter 7. Cyclase associated protein (CAP): The silent worker -- Chapter 8. Capping Protein (CP): The formin competitor -- Chapter 9. Coronin: An Overview -- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators -- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan.This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.Enginyeria de proteïnesthubParasitologyBiomechanicsProteinsBioinformaticsParasitologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B19002Biomechanicshttps://scigraph.springernature.com/ontologies/product-market-codes/L29020Protein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Protein Structurehttps://scigraph.springernature.com/ontologies/product-market-codes/L14050Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/L15001Llibres electrònicsthubEnginyeria de proteïnesParasitology.Biomechanics.Proteins.Bioinformatics.Parasitology.Biomechanics.Protein Science.Protein Structure.Bioinformatics.616.96Kale Avinashedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910373917803321Actin Polymerization in Apicomplexan1912463UNINA