04373nam 22006495 450 991037391690332120220314151420.0981-329-717-410.1007/978-981-32-9717-3(CKB)4100000009844763(DE-He213)978-981-32-9717-3(MiAaPQ)EBC5983832(PPN)242824064(EXLCZ)99410000000984476320191122d2019 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierCo-signal Molecules in T Cell Activation Immune Regulation in Health and Disease /edited by Miyuki Azuma, Hideo Yagita1st ed. 2019.Singapore :Springer Singapore :Imprint: Springer,2019.1 online resource (VI, 326 p. 22 illus., 21 illus. in color.)Advances in Experimental Medicine and Biology,0065-2598 ;1189981-329-716-6 Part I: Basic Understanding of Co-signal Molecules in T cell activation -- Chapter 1 Co-signal molecules in T cell activation -- Chapter 2 The CD28-B7 family of co-signaling molecules -- Chapter 3 The TNF YNFR family of co-signal molecules -- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors -- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation -- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation -- Chapter 7 Control of regulatory T cells by co-signal molecules -- Part II: Co-signal Molecules in Health and Disease -- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity -- Chapter 9 Co-signaling molecules in neurological diseases -- Chapter 10 Costimulation blockade in transplantation -- Chapter 11 Immunotherapy targeting co-signal molecules. .This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. .Advances in Experimental Medicine and Biology,0065-2598 ;1189ImmunologyCancer researchNeurology Oncology  Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Cancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Neurologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H36001Oncologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33160Cèl·lules TthubImmunologiathubLlibres electrònicsthubImmunology.Cancer research.Neurology .Oncology  .Immunology.Cancer Research.Neurology.Oncology.Cèl·lules TImmunologia616.079Azuma Miyukiedthttp://id.loc.gov/vocabulary/relators/edtYagita Hideoedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910373916903321Co-signal Molecules in T Cell Activation2140623UNINA