03736nam 22005655 450 991037390800332120220314152132.03-030-35362-110.1007/978-3-030-35362-9(CKB)4100000010011897(MiAaPQ)EBC6001559(DE-He213)978-3-030-35362-9(PPN)242817238(EXLCZ)99410000001001189720191224d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierConcepts and Principles of Pharmacology 100 Years of the Handbook of Experimental Pharmacology /edited by James E. Barrett, Clive P. Page, Martin C. Michel1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (viii, 466 pages) illustrationsHandbook of Experimental Pharmacology,0171-2004 ;2603-030-35361-3 Includes bibliographical references.Part 1. A Century of Advances in Pharmacology -- 1. Perspectives of Pharmacology Over the Past 100 years -- 2. Emergent concepts of receptor pharmacology -- 3. The Evolving Landscape of Cancer Therapeutics -- 4. Monoclonal Antibodies: Past, Present and Future -- 5. 100 years of Drug Delivery to the Lungs -- 6. Exploiting the Diversity of Ion Channels: Ion channel Pharmacology for Pain modulation -- 7. Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications -- Part 2. Recent developments and enabling technologies in pharmacology -- 8. Genetically Encoded Fluorescent Calcium and Voltage Indicators -- 9. Mechanistic Image-Based Modeling: Concepts and Applications of Image-Based Modeling -- 10. Pharmacometabonomics: The Prediction of Drug Effects Using Metabolic Profiling -- 11. The Microbiome and its Potential for Pharmacology -- 12. Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology -- Part 3. The future of pharmacology -- 13. The future of clinical trial design: The Transition from Hard Endpoints to Value-Based Endpoings -- 14. Placebos and the Placebo Effect in Drug Trials -- 15. Pharmacoepidemiology -- 16. Why are new drugs expensive and how can they stay affordable? .Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.Handbook of Experimental Pharmacology,0171-2004 ;260PharmacologyPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007PharmacologyFarmacologiathubLlibres electrònicsthubPharmacology.Pharmacology/Toxicology.PharmacologyFarmacologia615.7Barrett James Eedthttp://id.loc.gov/vocabulary/relators/edtPage Clive Pedthttp://id.loc.gov/vocabulary/relators/edtMichel Martin Cedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910373908003321Concepts and principles of pharmacology1765535UNINA