05097nam 2201273z- 450 9910372786403321202102113-03921-991-X(CKB)4100000010163762(oapen)https://directory.doabooks.org/handle/20.500.12854/54960(oapen)doab54960(EXLCZ)99410000001016376220202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNutrition and Eye HealthMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (242 p.)3-03921-990-1 Blindness and visual impairment impact significantly on an individual's physical and mental well-being. Loss of vision is a global health problem, with approximately 250 million of the world's population currently living with vision loss, of which 36 million are classified as blind. Visual impairment is more frequent in the elderly, with cataract and age-related macular degeneration (AMD) accounting for over 50% of cases globally. Oxidative stress has been strongly implicated in the pathogenesis of both conditions, and consequently the role of nutritional factors, in particular carotenoids and micronutrient antioxidants, have been investigated as possible preventative or therapeutic strategies. Dry eye syndrome (DES) is one of the most common ophthalmic conditions in the world. DES occurs where the eye does not produce enough tears and/or the tears evaporate too quicklyleading to discomfort and varying degrees of visual disturbance. There has recently been a great deal of interest in the potential for oral or topical supplementation with essential fatty acids (EFAs), specifically omega-3 and omega-6 fatty acids, as an adjunct to conventional treatments for DES. The objective of this Special Issue on 'Nutrition and Eye Health' is to publish papers describing the role of nutrition in maintaining eye health and the use of nutritional interventions to prevent or treat ocular disease. A particular (but not exclusive) emphasis will be on papers (reviews and/or clinical or experimental studies) relating to cataract, AMD and DES.Biology, life sciencesbicsscadvanced glycation end productsage-related macular degenerationAGREE IIAMDangiogenesisanti-inflammatoryanti-oxidantantioxidant supplementscarotenoidscataractchyrsinclinical practice guidelinesclinical surveyCODScorneal chemical burncorneal neovascularization (CNV)crocetincrocinCrocus Sativus L.Cucurbita argyrospermacyclooxigenase-2 (COX-2)diabetesdiabetic retinopathydietdietary antioxidantsdietary assessmentdietary habitsdrug discoverydry eyeelectroretinographyendoplasmic reticulumendoplasmic reticulum stressestrogen-deficient ratseye diseasefatty acidfish oilflavonoidsfood frequency questionnaireglaucomagut microbiotagut-retina axisinflammationinterleukin-1? (IL-1?)Lactobacillus paracasei KW3110lenslenseslightlight damageluteinmacrophagemesozeaxanthin (RS zeaxanthin)micronutrientsmicrovascular lesionsn/aneoangiogenesisnuclear factor-kappaB (NF-?B)nutritionnutritional supplementsomega-3omega-3 polyunsaturated fatty acidsoxidative stresspersonalised medicinephotoreceptor degenerationphytoconstituentspolyphenolspreclinical modelsreduced glutathioneretinaretinal pigment epitheliumrosmarinic acidRR-zeaxanthinsaffronsaponinssinapic acidsupplementssystematic reviewsvascular endothelial growth factor (VEGF)visual cycleBiology, life sciencesDownie Lauraauth1301184Lawrenson JohnauthBOOK9910372786403321Nutrition and Eye Health3025773UNINA