03731nam 2200985z- 450 9910372785703321202102113-03928-091-0(CKB)4100000010163769(oapen)https://directory.doabooks.org/handle/20.500.12854/48415(oapen)doab48415(oapen)48415(EXLCZ)99410000001016376920202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierGenome Mining and Marine Microbial Natural ProductsMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (202 p.)3-03928-090-2 Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.Biology, life sciencesbicssc16S rRNA metagenomicsactinobacteriaamino compoundAntarcticaantibacterialantibacterial activityantifungalantimicrobialantimicrobial activityarchaeabacillibactinbacillomycinbiosynthesisbiosynthetic gene clusterscarotenoidcomparative genomicscytotoxicitydrug discoveryecotypefatty acid amidefibrinolytic activitygene clustergenome mininghalo-extremophyleshaloenzymeshistone-deacetylase inhibitorIclR family regulatorisoindolinone biosynthesismarinemarine Bacillusmarine microorganismsmarine natural productmarine natural products (MNPs)Marisediminicolamedicinal chemistrymeroterpenoidmetal stress techniquenatural productsNdgRyononribosomal peptidesOdiel marshlandsPenicillium chrysogenumphylotypepolycyclic tetramate macrolactamspolyketide antibioticspolyketide synthasesecondary metabolitesspongeStachybotrysStreptomycesStreptomyces pratensisStreptomyces sp. SCSIO 40010Biology, life sciencesHong Kuiauth1301183Zhang ChangshengauthDobson A(Alan)authBOOK9910372785703321Genome Mining and Marine Microbial Natural Products3025772UNINA03217nam 2200901z- 450 9910637778203321202212063-0365-5538-2(CKB)5470000001631757(oapen)https://directory.doabooks.org/handle/20.500.12854/94491(oapen)94491(EXLCZ)99547000000163175720202212d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Trends in Cognitive Ageing and Mild Cognitive ImpairmentBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (130 p.)3-0365-5537-4 This book focuses on the process of cognitive ageing, considering the increase in cognitive impairment associated with the aging of the population and the related care impact. Special attention is given to cognitive health changes linked to the increase in life expectancy, including the role of subjective factors; the link between cognitive function, mobility and functionality; and the potential role of digital technologies, including computerized cognitive tests and virtual reality environments.Public health & preventive medicinebicsscPublic health and preventive medicinebicsscmemory lossvirtual realitytechnologynature environmentsqualitative researchdementialong-term carecognitive agingepidemiologyhealthcare disparitiesminority healthleisure activity engagementmeasurement of activitycognitive performanceaging adultssustained attention to response taskSARTmultimodal visualizationthresholdtimed up-and-gofallscognitionrepeated measuresmobility declinemolecular imagingICDs18F-FDG-PETParkinson's diseasedopamine agonistsmixed dementiabehavioral and psychological symptoms in dementiachallenging behaviorslockdowndepressionadjustment disorderglaucomahallucinationspolypharmacybalanceexerciseOtago Exercise ProgramPublic health & preventive medicinePublic health and preventive medicineFacal Davidedt1285495Spuch CarlosedtRodriguez Sonia ValladaresedtFacal DavidothSpuch CarlosothRodriguez Sonia ValladaresothBOOK9910637778203321New Trends in Cognitive Ageing and Mild Cognitive Impairment3019606UNINA