03594nam 2200937z- 450 991037278570332120231214133541.03-03928-091-0(CKB)4100000010163769(oapen)https://directory.doabooks.org/handle/20.500.12854/48415(EXLCZ)99410000001016376920202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierGenome Mining and Marine Microbial Natural ProductsMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (202 p.)3-03928-090-2 Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.antibacterial activitypolyketide synthasehalo-extremophylesantibacterialgene clusterPenicillium chrysogenumbacillomycinsecondary metabolitesdrug discoverybiosynthesispolycyclic tetramate macrolactamsactinobacteriabiosynthetic gene clustersphylotypecomparative genomicsIclR family regulatorpolyketide antibioticsantifungalfatty acid amideAntarcticamarine microorganismsNdgRyononribosomal peptidesMarisediminicolagenome miningantimicrobialspongeStachybotryscarotenoidmarinearchaeahaloenzymesnatural productsStreptomyces sp. SCSIO 4001016S rRNA metagenomicsecotypemedicinal chemistrycytotoxicitymarine natural products (MNPs)Streptomycesmarine Bacillusantimicrobial activityamino compoundbacillibactinmeroterpenoidfibrinolytic activitymetal stress techniqueisoindolinone biosynthesisStreptomyces pratensishistone-deacetylase inhibitormarine natural productOdiel marshlandsHong Kuiauth1301183Zhang ChangshengauthDobson AlanauthBOOK9910372785703321Genome Mining and Marine Microbial Natural Products3025772UNINA