06053nam 2201789z- 450 9910372785603321202102123-03921-849-2(CKB)4100000010163770(oapen)https://directory.doabooks.org/handle/20.500.12854/61237(oapen)doab61237(EXLCZ)99410000001016377020202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierTransmucosal Absorption Enhancers in the Drug Delivery FieldMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (406 p.)3-03921-848-4 Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled "Transmucosal Absorption Enhancers in the Drug Delivery Field" aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.Medicinebicsscabsorption enhancementabsorption enhancerabsorption enhancersabsorption modifying excipientsAloe veraamino acidamphiphilic polymersand liposomeantiepileptic drugantimicrobial peptidebiocompatibility studiesbioenhancerblock copolymersbrush borderCaco-2Caco-2 cellscationic functionalizationcell-penetrating peptidecell-penetrating peptide (CPP)cervicovaginal tumorschitosanchitosan derivativesclaudinclinical trialCNS disorderscombined microspherecompound 48/80confocal laser scanning microscopycorneacurcumincyclodextrincytochrome P450drug absorption enhancerdrug administrationdrug deliveryeffluxenterocyteepithelial permeabilityepithelial transportepitheliumF-actinFITC-dextranformulationgelgemini surfactantGLP-1hydrophobizationimatinibin situ hydrogelin vivo studiesinsulinintestinal absorptionintestinal deliveryintestinal epithelial cellsintestinal permeation enhancersKLALmanmast cell activatormetabolismmucoadhesionmucoadhesivenessN-dodecyl-?-D-maltoside (DDM)nanocapsulesnanocrystalsnanomedicinenanoparticlenanoparticlesnasalnasal deliverynasal formulationnasal permeabilitynasal vaccinationnose to brain deliverynose to brain transportnose-to-brainocular conditionsocular deliveryocular drug deliveryophthalmologyoral deliveryoral macromolecule deliveryoral peptidesosteoporosisP-glycoproteinpenetration enhancerpenetration enhancerspermeabilitypermeation enhancerpermeation enhancerspharmacokinetic interactionpharmacokineticsPN159polymeric micellespoorly absorbed drugpreclinicalPTH 1-34pulmonaryquaternizationsafetysalcaprozate sodiumsheepsimulated intestinal fluidsimvastatinsmall intestinesodium capratesodium cholate (NaC)sugar-based surfactantsteriparatidethermogel systemtight junctiontight junction modulatortight junctionstransepithelial electrical resistancetransferrintransmucosal drug deliverytransmucosal permeationtryptophanvaccine adjuvantvaginal deliverywhole leafMedicineMaher Samauth1322342Illum LisbethauthCasettari LucaauthBOOK9910372785603321Transmucosal Absorption Enhancers in the Drug Delivery Field3034888UNINA