05982nam 2201753z- 450 991037278560332120231214133526.03-03921-849-2(CKB)4100000010163770(oapen)https://directory.doabooks.org/handle/20.500.12854/61237(EXLCZ)99410000001016377020202102d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierTransmucosal Absorption Enhancers in the Drug Delivery FieldMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (406 p.)3-03921-848-4 Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.chitosanintestinal epithelial cellsocular deliveryamphiphilic polymerscorneatight junction modulatorcyclodextrinpermeabilitygemini surfactanttransferrincompound 48/80epithelial permeabilitycervicovaginal tumorsnanoparticlesconfocal laser scanning microscopysafetyformulationsalcaprozate sodiumintestinal absorptionFITC-dextrancurcuminblock copolymersnasal vaccinationwhole leafbrush borderocular drug deliveryvaccine adjuvantnanoparticlenasal deliveryeffluxpermeation enhancersabsorption enhancersnose to brain deliverysmall intestineepitheliumCNS disordersabsorption modifying excipientsinsulinabsorption enhancergelintestinal deliverythermogel systemCaco-2biocompatibility studiesabsorption enhancementmanPN159poorly absorbed drugtryptophantight junctionoral macromolecule deliverypenetration enhancerintestinal permeation enhancersnanocrystalssimvastatinnanomedicineenterocyteN-dodecyl-?-D-maltoside (DDM)cell-penetrating peptidequaternizationKLALnasalnasal permeabilitytransmucosal drug deliveryCaco-2 cellsmast cell activatorpenetration enhancersdrug deliverynose-to-brainbioenhancerpolymeric micellesmucoadhesioncell-penetrating peptide (CPP)simulated intestinal fluidvaginal deliverynasal formulationpharmacokinetic interactionsodium caprateclinical trialtransmucosal permeationdrug absorption enhancersugar-based surfactantsnanocapsulesimatinibteriparatideosteoporosishydrophobizationF-actincombined microspheretransepithelial electrical resistanceoral deliveryocular conditionsmetabolismantimicrobial peptidepermeation enhancerdrug administrationantiepileptic drugamino acidin vivo studiessodium cholate (NaC)epithelial transportpreclinicalnose to brain transportpharmacokineticschitosan derivativesophthalmologytight junctionssheepcationic functionalizationGLP-1pulmonaryand liposomecytochrome P450claudinP-glycoproteinin situ hydrogelmucoadhesivenessPTH 1-34Aloe veraoral peptidesMaher Samauth1322342Illum LisbethauthCasettari LucaauthBOOK9910372785603321Transmucosal Absorption Enhancers in the Drug Delivery Field3034888UNINA