05142nam 22012853a 450 991036775700332120250203235429.09783039211531303921153610.3390/books978-3-03921-153-1(CKB)4100000010106147(oapen)https://directory.doabooks.org/handle/20.500.12854/56626(ScCtBLL)95f615b6-8862-45fa-a25e-11c9a21fe073(OCoLC)1163835999(EXLCZ)99410000001010614720250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierPolyamine Metabolism in Disease and Polyamine-Targeted TherapiesTracy Murray-StewartBasel, Switzerland :MDPI,2019.1 electronic resource (240 p.)9783039211524 3039211528 Spermine, spermidine, and putrescine constitute the mammalian polyamines, abundant polycations with essential roles in critical cell functions. As such, intracellular polyamine concentrations are tightly regulated through biosynthesis, catabolism, and transport. The multifaceted effects of polyamine dysregulation have contributed to its role in multiple disease processes but have also implicated it as target for preventive or therapeutic intervention. The correlation between oncogene-mediated elevation of polyamine biosynthesis and cancer is well established, and induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines concentrations are reported to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.protein synthesis in cancerneuroblastomaepigeneticsDrosophila imaginal discspneumococcal pneumoniatransgenic micespermidine/spermine N1-acetyl transferase?-difluoromethylornithineMYCskeletal muscleprotein expressioncurcumincolorectal cancerautophagyhuman embryonic kidney 293 (HEK293)melanomatumor immunitySnyder-Robinson SyndromeStreptococcus pneumoniaeB-lymphocytesautoimmunityspermine oxidasecell differentiationdiferuloylmethaneimmunityantizymetransgenic mousepolyaminehirsutismchemopreventionCRISPRtransglutaminasepolyamine analogsNF-?Bspermine synthaseatrophyagingoxidative stressmast cellsAfrican sleeping sicknesspancreatic ductal adenocarcinomaeflornithinecarcinogenesisornithine decarboxylasepolyamine transport inhibitorputrescineneutrophilsspermidineuntranslated regionsperminepolyphenolM2 macrophagespolyamine transport systemmetabolismdifluoromethylorthinineDFMOantizyme inhibitorscapsulepolyamine transporteosinophilsMCF-7 cellsdifluoromethylornithinepolyamine metabolismmutant BRAFpolyaminescadaverineproteomicsairway smooth muscle cellsbreast cancerX-linked intellectual disabilitycomplementationT-lymphocytesbis(ethyl)polyamine analogsantizyme 1cancerosteosarcomaMurray-Stewart Tracy1309855ScCtBLLScCtBLLBOOK9910367757003321Polyamine Metabolism in Disease and Polyamine-Targeted Therapies3029658UNINA