05704nam 2201201z- 450 991036775700332120231214133146.03-03921-153-6(CKB)4100000010106147(oapen)https://directory.doabooks.org/handle/20.500.12854/56626(EXLCZ)99410000001010614720202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPolyamine Metabolism in Disease and Polyamine-Targeted TherapiesMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (240 p.)3-03921-152-8 Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.protein synthesis in cancerneuroblastomaepigeneticsDrosophila imaginal discspneumococcal pneumoniatransgenic micespermidine/spermine N1-acetyl transferase?-difluoromethylornithineMYCskeletal muscleprotein expressioncurcumincolorectal cancerautophagyhuman embryonic kidney 293 (HEK293)melanomatumor immunitySnyder-Robinson SyndromeStreptococcus pneumoniaeB-lymphocytesautoimmunityspermine oxidasecell differentiationdiferuloylmethaneimmunityantizymetransgenic mousepolyaminehirsutismchemopreventionCRISPRtransglutaminasepolyamine analogsNF-?Bspermine synthaseatrophyagingoxidative stressmast cellsAfrican sleeping sicknesspancreatic ductal adenocarcinomaeflornithinecarcinogenesisornithine decarboxylasepolyamine transport inhibitorputrescineneutrophilsspermidineuntranslated regionsperminepolyphenolM2 macrophagespolyamine transport systemmetabolismdifluoromethylorthinineDFMOantizyme inhibitorscapsulepolyamine transporteosinophilsMCF-7 cellsdifluoromethylornithinepolyamine metabolismmutant BRAFpolyaminescadaverineproteomicsairway smooth muscle cellsbreast cancerX-linked intellectual disabilitycomplementationT-lymphocytesbis(ethyl)polyamine analogsantizyme 1cancerosteosarcomaMurray-Stewart Tracyauth1309855BOOK9910367757003321Polyamine Metabolism in Disease and Polyamine-Targeted Therapies3029658UNINA