03503nam 2200949z- 450 991036775620332120231214133032.03-03921-502-7(CKB)4100000010106155(oapen)https://directory.doabooks.org/handle/20.500.12854/57786(EXLCZ)99410000001010615520202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRecent Progress in Solid Dispersion TechnologyMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (204 p.)3-03921-501-9 Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.thermodynamic modelingmolecular dynamics simulationpoorly soluble drugsamorphous solid dispersionsdissolution enhancementcrystallization tendencycontinuous processingstabilitymillinggranulationthermal analysisamorphousball millingpharmaceutical glassdissolutionrebamipidepoloxamerclassificationpolyelectrolytesamorphisationself-assemblydissolution ratemiscibilitybioavailabilitysolubilityevaporationmesoporouspolyelectrolyte excipient matrixpolymerbicaludamidephase diagramWeibull dissolution modelspectroscopic techniquesanticancer drugsmanufacturing methodsnucleationmolecular complexnanoaggregatesenrofloxacinaccelerated stability testsolubility enhancementamorphous solid dispersiontadalafilprocess developmentamorphous polymeric saltWood’s apparatushot melt extrusionsolid dispersionsintrinsic dissolution ratesolid dispersioninteractioncrystallizationspray dryingcharacterizationciprofloxacinKawakami Kohsakuauth1328855BOOK9910367756203321Recent Progress in Solid Dispersion Technology3039034UNINA