03920nam 22010813a 450 991036775620332120250203235433.09783039215027303921502710.3390/books978-3-03921-502-7(CKB)4100000010106155(oapen)https://directory.doabooks.org/handle/20.500.12854/57786(ScCtBLL)5fb4a170-33eb-494e-81d6-dc3bace0e1dc(OCoLC)1163805664(oapen)doab57786(EXLCZ)99410000001010615520250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierRecent Progress in Solid Dispersion TechnologyKohsaku KawakamiMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (204 p.)9783039215010 3039215019 Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.Biology, life sciencesbicsscthermodynamic modelingmolecular dynamics simulationpoorly soluble drugsamorphous solid dispersionsdissolution enhancementcrystallization tendencycontinuous processingstabilitymillinggranulationthermal analysisamorphousball millingpharmaceutical glassdissolutionrebamipidepoloxamerclassificationpolyelectrolytesamorphisationself-assemblydissolution ratemiscibilitybioavailabilitysolubilityevaporationmesoporouspolyelectrolyte excipient matrixpolymerbicaludamidephase diagramWeibull dissolution modelspectroscopic techniquesanticancer drugsmanufacturing methodsnucleationmolecular complexnanoaggregatesenrofloxacinaccelerated stability testsolubility enhancementamorphous solid dispersiontadalafilprocess developmentamorphous polymeric saltWood’s apparatushot melt extrusionsolid dispersionsintrinsic dissolution ratesolid dispersioninteractioncrystallizationspray dryingcharacterizationciprofloxacinBiology, life sciencesKawakami Kohsaku1328855ScCtBLLScCtBLLBOOK9910367756203321Recent Progress in Solid Dispersion Technology3039034UNINA