05483nam 22014293a 450 991036775470332120250203235431.09783039211906303921190010.3390/books978-3-03921-190-6(CKB)4100000010106170(oapen)https://directory.doabooks.org/handle/20.500.12854/61900(ScCtBLL)7f92ff81-7eac-47f9-98c7-07aa248d0431(OCoLC)1163853203(oapen)doab61900(EXLCZ)99410000001010617020250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierVenom and Toxin as Targeted TherapyHang Fai Henry KwokMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (180 p.)9783039211890 3039211897 Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.Biology, life sciencesbicssccane toadB cell non-Hodgkin lymphomaMalaysian cobrascomplement systemdecay accelerating factorneuroblastomaatopic dermatitiscomplement dependent cytotoxicityantioxidant enzymesbacterial adhesioncancer therapyN. kaouthiaanuran skin secretionfrogApis mellifera syriacasolid phase extractionbee venom phospholipase A2 (bvPLA2)disintegrintoad toxinsimmunotoxinsribosome-inactivating proteinsantimicrobial peptide (AMP)drug designMoxetumomab pasudotoxsnake venomantiviral activityin vitro effectsbombesin-related peptideoxidative stress biomarkershalf-lifeblood vessel formationtarget therapy2MYCNindolealkylaminesHuachansumembrane attack complexbouganinbee venomSEManticancer activityantimicrobial peptidehouse dust mite extract (DFE)mannose receptorO. hannahbicarinalingastric cellsmelittinLC-ESI-MSdermaseptinsmooth muscleapoptosisanticancerN. sumatranaHelicobacter pyloriinflammationimmunotherapyatopic dermatitis (AD)immunotoxinmantle cell lymphomaclearancemass spectrometryBougainvillearRNA N-glycosylase activityfungal toxinskin inflammationtargeted therapy4-dinitrochlorobenzene (DNCB)Bee venomVEGFChansubufadienolidesobsessive-compulsive disorder (OCD)BLF1antimicrobial activityorellanineVB6-845acute lymphoblastic leukemiaribosome-inactivating proteinCD206molecular cloningcancerCD22eIF4ABiology, life sciencesKwok Hang Fai Henry1320455ScCtBLLScCtBLLBOOK9910367754703321Venom and Toxin as Targeted Therapy3034329UNINA04027nam 22006735 450 991034944230332120251113202324.03-030-22907-610.1007/978-3-030-22907-8(CKB)4100000009382571(DE-He213)978-3-030-22907-8(MiAaPQ)EBC5927961(PPN)260303968(EXLCZ)99410000000938257120190924d2019 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierHuman Epigenetics: How Science Works /by Carsten Carlberg, Ferdinand Molnár1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (XVI, 153 p. 69 illus. in color.)3-030-22906-8 Introduction -- Chromatin and gene expression -- DNA methylation -- Histone modifications -- Chromatin modifying proteins and RNAs -- Embryogenesis and cellular differentiation -- Population epigenetics and aging -- Cancer epigenetics -- Neuroepigenetics -- Nutritional epigenetics -- Epigenetics of immune function -- Epigenome-environment interactions and their therapy.The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and are able to prevent the onset of diseases, such a type 2 diabetes or cancer. This book provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells forming our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.Molecular geneticsMedicineResearchBiologyResearchNutritionCancerImmunologyMolecular GeneticsBiomedical ResearchNutritionCancer BiologyImmunologyMolecular genetics.MedicineResearch.BiologyResearch.Nutrition.Cancer.Immunology.Molecular Genetics.Biomedical Research.Nutrition.Cancer Biology.Immunology.573.21Carlberg Carstenauthttp://id.loc.gov/vocabulary/relators/aut849346Molnár Ferdinandauthttp://id.loc.gov/vocabulary/relators/autMiAaPQMiAaPQMiAaPQBOOK9910349442303321Human Epigenetics: How Science Works2184138UNINA