04015nam 2200973z- 450 991036775140332120231214133437.03-03921-583-3(CKB)4100000010106203(oapen)https://directory.doabooks.org/handle/20.500.12854/53824(EXLCZ)99410000001010620320202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular Basis of Cardiovascular Diseases: Implications of Natriuretic PeptidesMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (212 p.)3-03921-582-5 The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.Molecular Basis of Cardiovascular Diseasespostmortem biochemistrymedullaanimal modelsremodelingBNPPCSK9guanylyl cyclase/natriuretic peptide receptor-Acardiorenal syndromeforensic medicinepreserved ejection fractionkidneyrenin-angiotensin-aldosterone systematrial fibrillationvasopressorcongestive heart failureatrial natriuretic peptidegene-knockoutobesityheart failureangiogenesisadipose tissuevascularLDL receptormetabolic syndromelinkage analysiscardiometabolic diseasecardiomyocytecardiac dysfunctioncardiac hypertrophyinsulinlipid metabolismcGMPIdiopathic Pulmonary Arterial Hypertension (IPAH)Natriuretic Peptide Clearance Receptor (NPR-C) signalinggene-duplicationrenin–angiotensin systemnatriuretic peptidesangiotensin receptor–neprilysin inhibitorcardiac remodellingARNiNT-proBNPinflammationpulmonary arterial hypertensionvascular homeostasisendothelial cellAtrial Natriuretic peptidenatriuretic peptidevasodilatorstrokegenetic variantsarterial hypertensionfibroblastMANPhypertensionguanylyl cyclase receptor ARubattu Speranzaauth1324890Volpe MassimoauthBOOK9910367751403321Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides3036447UNINA