03949nam 2201213z- 450 991036775040332120231214133409.03-03921-408-X(CKB)4100000010106213(oapen)https://directory.doabooks.org/handle/20.500.12854/53845(EXLCZ)99410000001010621320202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular Mechanism of Alzheimer's DiseaseMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (228 p.)3-03921-407-1 Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.HOTAIRneurosciencessleep disturbancepositron emission tomography (PET)vitamin B complexneurodegenerationTaumiR-15/107default-mode networkcomplement receptor 1neuronal differentiationepigeneticsbrain glucose metabolismoligomerizationgenetic riskA?O receptorsprionryanodine receptortype 3 diabetescomplementcognitive behavioral therapy for insomniacognitive functionepigenome-wide association studyAlzheimer’s diseasecalcium signaling?-secretasetauProlyl isomerasesNEAT1complement C3b/C4b receptorproteostasisamyloid betayeastslow-wave sleepamyloid ?nutrition4protein aggregationapolipoprotein EdementiaMALAT1inositol 1lncRNAsmolecular biologymethylenetetrahydrofolate reductase MTHFR gene5-trisphosphate receptorCR1 densitymiR-34caggregationheat shock proteindendritic spineS-adenosylmethioninebeta amyloidion channelinflammationsleep fragmentationcystathionine-?-lyase CTH geneDNA methylationheat shock responsemicrogliadrug target discoveryamyloid-? oligomertherapyCR1 length polymorphismmethylomeAPOE geneubiquitinmagnetic resonance imaging (MRI)neuronal degenerationtype 2 diabetesPin1mild cognitive impairmentdairy productsendoplasmic reticulumoxidative stressHispanicsCDK5R1Macreadie Ianauth1325223BOOK9910367750403321Molecular Mechanism of Alzheimer's Disease3036703UNINA