04361nam 22013453a 450 991036775040332120250203235427.09783039214082303921408X10.3390/books978-3-03921-408-2(CKB)4100000010106213(oapen)https://directory.doabooks.org/handle/20.500.12854/53845(ScCtBLL)db69e1af-5782-4846-81f7-14c2b9141c10(OCoLC)1163824875(oapen)doab53845(EXLCZ)99410000001010621320250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular Mechanism of Alzheimer's DiseaseIan MacreadieMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (228 p.)9783039214075 3039214071 Alzheimer's disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer's disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.Biology, life sciencesbicsscHOTAIRneurosciencessleep disturbancepositron emission tomography (PET)vitamin B complexneurodegenerationTaumiR-15/107default-mode networkcomplement receptor 1neuronal differentiationepigeneticsbrain glucose metabolismoligomerizationgenetic riskA?O receptorsprionryanodine receptortype 3 diabetescomplementcognitive behavioral therapy for insomniacognitive functionepigenome-wide association studyAlzheimer’s diseasecalcium signaling?-secretasetauProlyl isomerasesNEAT1complement C3b/C4b receptorproteostasisamyloid betayeastslow-wave sleepamyloid ?nutrition4protein aggregationapolipoprotein EdementiaMALAT1inositol 1lncRNAsmolecular biologymethylenetetrahydrofolate reductase MTHFR gene5-trisphosphate receptorCR1 densitymiR-34caggregationheat shock proteindendritic spineS-adenosylmethioninebeta amyloidion channelinflammationsleep fragmentationcystathionine-?-lyase CTH geneDNA methylationheat shock responsemicrogliadrug target discoveryamyloid-? oligomertherapyCR1 length polymorphismmethylomeAPOE geneubiquitinmagnetic resonance imaging (MRI)neuronal degenerationtype 2 diabetesPin1mild cognitive impairmentdairy productsendoplasmic reticulumoxidative stressHispanicsCDK5R1Biology, life sciencesMacreadie Ian1325223ScCtBLLScCtBLLBOOK9910367750403321Molecular Mechanism of Alzheimer's Disease3036703UNINA