04043nam 2201021z- 450 9910367743003321202102113-03921-821-2(CKB)4100000010106287(oapen)https://directory.doabooks.org/handle/20.500.12854/52775(oapen)doab52775(EXLCZ)99410000001010628720202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMarine Glycobiology, Glycomics and LectinsMDPI - Multidisciplinary Digital Publishing Institute20191 online resource (176 p.)3-03921-820-4 Glycans (carbohydrate chains) of marine creatures are rich and diverse in polysaccharides, glycoproteins, and glycolipids. The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. Marine glycomics that involves the genome and transcriptome accelerates our understanding of the evolution of glycans, glycan-related enzymes, and lectins. From 2017 to 2019, the Special Issue "Marine Glycobiology, Glycomics and Lectins" of the journal Marine Drugs published scientific articles and reviews, on the background of "glycobiology"-that is, glycan-based biosciences. The aim was to promote the discovery of novel biomolecules that contribute to drug development and clinical studies. This has great potential for establishing connections between the fields of both human health and marine life sciences.This book contains 11 scientific papers representing current topics in comprehensive glycosciences related to therapeutic agents from marine natural products, as outlined.Biology, life sciencesbicssc?-galactosidase?-secretaseadverse effectsAlzheimer's diseaseamyloid-?anti-viralanticoagulant activitiesapoptosis-related genesBACE1bioactivitybivalve mollusksC1qcomplement systemdifferentiation inductionDNA methyltransferasesEhrlich ascites carcinomaepigenetic modificationERKfucan sulfatefucoidanfucosylated glycosaminoglycanFucus distichus subsp. evanescensgalactooligosaccharidesglioblastomaglycosaminoglycanHddSBLheparan sulphateheparininnate immunitylectinlectinsmalignant gliomaMarinomonasMytiLec-1Mytilus galloprovincialisnanomedical devicesnematocyst discharge processnematogalectinoligo-fucoidanoncolytic vaccinia virusoxidative stressPattalus mollispattern recognition receptorsphagocytosisphysicochemical characteristicspolysialic acid (polySia)Portunus pelagicusrecombinantretinal pigment epitheliumtandem duplicationtheoretical modeltherapeutic effectsthermostabletoxicitytransglycosylationTTLVEGFviral replicationBiology, life sciencesOzeki Yasuhiroauth1312846BOOK9910367743003321Marine Glycobiology, Glycomics and Lectins3031021UNINA