04082nam 2201057z- 450 9910367742003321202102113-03921-777-1(CKB)4100000010106297(oapen)https://directory.doabooks.org/handle/20.500.12854/45263(oapen)doab45263(EXLCZ)99410000001010629720202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDisease and the Hippo Pathway: Cellular and Molecular MechanismsMDPI - Multidisciplinary Digital Publishing Institute20191 online resource (226 p.)3-03921-776-3 The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.Disease and the Hippo PathwayBiology, life sciencesbicsscadaptive immunityangiogenesisanti-cancer therapyautoimmunitycancercancer immunitycastration resistancechromatinECMEMTepigeneticfeedback loopsfibroblastsfibrosisG protein-coupled receptorGPCRHippohippo pathwayHippo pathwayHippo signallinginnate immunityLATSLATS (large tumor suppressor kinase)LATS1/2Lats2Mps one binderMSTMST (mammalian STE20-like protein kinase)MST1/2myofibroblastn/aNDRperipheral nerve sheath tumorphosphorylationprostate cancerprotein kinaseprotein-protein interactionsschwannomasignal cross-talksignal transductionskin cancerskin developmentstem cellstem cellsSTK38STRIPAKstructure biologyTazTAZTAZ (transcriptional co-activator with PDZ-binding motif)TEADtranscriptiontumorigenesisvascular mimicrywound healingYapYAPYAP (yes-associated protein)YAP/TAZzebrafishBiology, life sciencesHansen Carsten Gramauth1297549BOOK9910367742003321Disease and the Hippo Pathway: Cellular and Molecular Mechanisms3024533UNINA