03959nam 2201009z- 450 991036774200332120231214133205.03-03921-777-1(CKB)4100000010106297(oapen)https://directory.doabooks.org/handle/20.500.12854/45263(EXLCZ)99410000001010629720202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDisease and the Hippo Pathway: Cellular and Molecular MechanismsMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (226 p.)3-03921-776-3 The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.Disease and the Hippo PathwaySTRIPAKskin cancerLats2transcriptionmyofibroblastepigeneticHippocancer immunityTAZTazTAZ (transcriptional co-activator with PDZ-binding motif)adaptive immunityfibroblastsinnate immunityLATSMST (mammalian STE20-like protein kinase)phosphorylationstem cellswound healingsignal transductionangiogenesisLATS1/2EMTprotein-protein interactionsstructure biologyHippo pathwayhippo pathwayautoimmunityMps one binderYAP/TAZGPCRfibrosisMST1/2YAP (yes-associated protein)YAPYapprotein kinaseLATS (large tumor suppressor kinase)peripheral nerve sheath tumorsignal cross-talkstem cellskin developmentSTK38tumorigenesisNDRschwannomaG protein-coupled receptoranti-cancer therapyfeedback loopsvascular mimicrycastration resistancechromatinHippo signallingECMMSTprostate cancerTEADcancerzebrafishHansen Carsten Gramauth1297549BOOK9910367742003321Disease and the Hippo Pathway: Cellular and Molecular Mechanisms3024533UNINA