04316nam 2201069z- 450 991036774090332120231214133621.03-03921-689-9(CKB)4100000010106308(oapen)https://directory.doabooks.org/handle/20.500.12854/45547(EXLCZ)99410000001010630820202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDual Specificity Phosphatases: From Molecular Mechanisms to Biological FunctionMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (240 p.)3-03921-688-0 Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.Dual Specificity Phosphataseshematopoietic cellsDEPArrayneuroblastomaliver steatosisMAPK phosphataseDUSP-4granule neuronsneuronal differentiationDUSP10cytokinesMAPKssingle cell analysismacrophageasthmaE. coli infectionMAPKCpp1nucleotide receptorsatypical DUSPRSVPmp1cannabinoidsastrocytessepsisinfluenzasignalingtriple-negative breast cancer (TNBC)differentiationHDAC6 (histone deacetylase isoform 6)atypical dual-specificity phosphatasesmicrotubulesrespiratory virusesMK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein)dual-specificity phosphataseMsg5TLR signalingmitogen-activated protein kinasefungal MKPsmacrophagesMAP Kinase Phosphatase-2inflammationSdp1circulating tumor cells (CTCs)MAP kinasesMAP kinase phosphatasesP2X7proliferationBDNFP2Y13T cellhypertriglyceridemiaintegrated omics analysispost-translational modificationrhinovirusprotein stabilityubiquitinationdual-specificity phosphatasesMkp-1cancerbrain metastasisHER2COPDpseudophosphatasePulido Rafaelauth1323466Lang RolandauthBOOK9910367740903321Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function3035585UNINA