04439nam 2201117z- 450 9910367740903321202102113-03921-689-9(CKB)4100000010106308(oapen)https://directory.doabooks.org/handle/20.500.12854/45547(oapen)doab45547(EXLCZ)99410000001010630820202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDual Specificity Phosphatases: From Molecular Mechanisms to Biological FunctionMDPI - Multidisciplinary Digital Publishing Institute20191 online resource (240 p.)3-03921-688-0 Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.Dual Specificity PhosphatasesBiology, life sciencesbicsscasthmaastrocytesatypical dual-specificity phosphatasesatypical DUSPBDNFbrain metastasiscancercannabinoidscirculating tumor cells (CTCs)COPDCpp1cytokinesDEPArraydifferentiationdual-specificity phosphatasedual-specificity phosphatasesDUSP-4DUSP10E. coli infectionfungal MKPsgranule neuronsHDAC6 (histone deacetylase isoform 6)hematopoietic cellsHER2hypertriglyceridemiainflammationinfluenzaintegrated omics analysisliver steatosismacrophagemacrophagesMAP Kinase Phosphatase-2MAP kinase phosphatasesMAP kinasesMAPKMAPK phosphataseMAPKsmicrotubulesmitogen-activated protein kinaseMK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein)Mkp-1Msg5n/aneuroblastomaneuronal differentiationnucleotide receptorsP2X7P2Y13Pmp1post-translational modificationproliferationprotein stabilitypseudophosphataserespiratory virusesrhinovirusRSVSdp1sepsissignalingsingle cell analysisT cellTLR signalingtriple-negative breast cancer (TNBC)ubiquitinationBiology, life sciencesPulido Rafaelauth1323466Lang RolandauthBOOK9910367740903321Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function3035585UNINA