04183nam 2201009z- 450 9910367737603321202102113-03921-851-4(CKB)4100000010106341(oapen)https://directory.doabooks.org/handle/20.500.12854/53201(oapen)doab53201(EXLCZ)99410000001010634120202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMERS-CoVMDPI - Multidisciplinary Digital Publishing Institute20191 online resource (274 p.)3-03921-850-6 Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus. First identified in 2012, MERS-CoV has caused over 2460 infections and a fatality rate of about 35% in humans. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV likely originated from bats; however, different from SARS-CoV, which potentially utilized palm civets as its intermediate hosts, MERS-CoV likely transmits to humans through dromedary camels. Animal models, such as humanized mice and nonhuman primates, have been developed for studying MERS-CoV infection. Currently, there are no vaccines and therapeutics approved for the prevention and treatment of MERS-CoV infection, although a number of them have been developed preclinically or tested clinically. This book covers one editorial and 16 articles (including seven review articles and nine original research papers) written by researchers working in the field of MERS-CoV. It describes the following three main aspects: (1) MERS-CoV epidemiology, transmission, and pathogenesis; (2) current progress on MERS-CoV animal models, vaccines, and therapeutics; and (3) challenges and future prospects for MERS-CoV research. Overall, this book will help researchers in the MERS-CoV field to further advance their work on the virus. It also has important implications for other coronaviruses as well as viruses outside the coronavirus family with pandemic potentials.Biology, life sciencesbicsscanimal modelanimal modelsauthentic viruscamelscell-cell fusioncombinationcomplementCoronaviruscoronavirus spike glycoproteincoronavirusescorrelates of immunitycross-neutralizationDPP4Driversfusion inhibitorHCoV-229EhDPP4HKU4host factorsinflammationlipidomicsmechanism of actionMERS-coronavirusMERS-CoVMERS-CoV nucleocapsid proteinMiddle East respiratory syndrome coronavirusMiddle East Respiratory Syndrome Virusmouse modelmurine CD8+ T cell epitopemutationMVA vaccinen/ananobodiesneutralizing antibodyneutralizing monoclonal antibodiesOne Healthpathogenesispeptideprevention and treatmentpseudotyped viruspyroptosisQatarrabbitsRBDreceptor-binding domainSARS-CoVsevere acute respiratory syndrome coronavirussmall-molecule inhibitorspike proteinspike proteinstherapeutic antibodiestherapeuticstransmissionUHPLC-MSvaccine platformsvaccinesBiology, life sciencesDu Lanyingauth1322339Li FangauthBOOK9910367737603321MERS-CoV3034884UNINA