05446nam 22013213a 450 991036756930332120250203235431.09783039211517303921151X10.3390/books978-3-03921-151-7(CKB)4100000010106053(oapen)https://directory.doabooks.org/handle/20.500.12854/42951(ScCtBLL)6e4195a6-7656-4146-9807-20653b914032(OCoLC)1163821515(oapen)doab42951(EXLCZ)99410000001010605320250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Challenges of Water Management and Governance in CitiesPeter Driessen, Jan Hofman, Cornelis Johannes (Kees) van Leeuwen, Jos FrijnsMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (314 p.)9783039211500 3039211501 Global population growth is urban growth and, therefore, most of the water-related challenges and solutions reside in cities. Unless water management and water governance processes are significantly improved within the next decade or so, cities are likely to face serious and prolonged water insecurity, urban floods, and/or heat stress, which may result in social instability and, ultimately, massive migration. Aging water infrastructure, one of the most expensive infrastructures in cities, is a relevant challenge in order to address Sustainable Development Goal (SDG) 6: clean water and sanitation, SDG 11: sustainable cities and communities, and SDG 13: climate action. The choice of good governance arrangements has important consequences for economic performance, for the well-being of citizens, and for the quality of life in urban areas. The better governance arrangements work in coordinating policies across jurisdictions and policy fields, the better the outcomes. Rapidly-changing global conditions will make future water governance more complex than ever before in human history, and expectations are that water governance and water management will change more during the next 20 years compared to the past 100 years. In this Special Issue of Water, the focus will be on practical concepts and tools for water management and water governance, with a focus on cities.flood resilienceflood riskCape TownSustainable Development Goals (SDGs)sustainable development goalsurban planningcoordinationIHPstorm water managementstakeholder involvementflood risk managementwater management sustainabilityGeneralized Likelihood Uncertainty Estimation (GLUE)climate changeurban water cyclewastewater managementwater policygovernance capacitygreenhouse gas emissionsintergovernmentalUrban Water Management Programmeindicatorssustainabilitycity networkswater sensitive citieswater scarcityICLEIflood damage assessmentstakeholder participationSuDSclimate change mitigationsocial network analysiswater ecologySDGsurban resiliencedesign rainfall eventcost of inactionrainwater harvestingco-designUNESCOrainfall-runoffstorm water control measuredecentralized water reclamation with resource recoverybaseline assessmentCity Blueprint Approachurban water managementurban landscapegovernance strategiesscience and technologydrinking waterIntegrated Water Resources ManagementresilienceSponge Citystormwater reservoiruse-attainmentsustainability assessmentwater securityWater-Energy-Food Nexuswater managementwater supplyStorm Water Management Model (SWMM)urban drainagelifecycle analysissocial infrastructureurban pluvial floodingassessment frameworkfootprintclimate change adaptationinfrastructuretotal cost of ownershipwater governanceflood controlwater-reusegovernanceDriessen Peter1788355Hofman Janvan Leeuwen Cornelis Johannes (Kees)Frijns JosScCtBLLScCtBLLBOOK9910367569303321The Challenges of Water Management and Governance in Cities4323172UNINA05702nam 22013693a 450 991036775370332120250203235427.09783039214501303921450010.3390/books978-3-03921-450-1(CKB)4100000010106180(oapen)https://directory.doabooks.org/handle/20.500.12854/44401(ScCtBLL)dd62bf84-dafe-4da1-8b78-b9defe0372a2(OCoLC)1163805900(oapen)doab44401(EXLCZ)99410000001010618020250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierCurcumin in Health and DiseaseBeatrice BachmeierMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (274 p.)9783039214495 3039214497 The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin's antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs' therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.Chemistrybicsscmineralscancer treatmentchitosanneurodegenerationantioxidant activitysenescencetumor proliferationnanoparticlesantimicrobial agentsoxidative metabolitesdrug discoveryAkt/mTOR signalingmicronutrientsulcerative colitistransmission electron microscopymetabolic reprogrammingcurcumindeath receptorchaperone-mediated autophagywound healingbrain ischemiaautophagyAlzheimer's diseasegenestransthyretininflammatory bowel diseasecellular pathwaycentrifugal partition chromatographynutritionamyloidCurcuma longaprotein aggregationsupportive careIL-17senolyticscomplementary medicinemacronutrientsstructure activity relationshipgastroprotectionZingiberaceaeanti-inflamationTLC bioautographymicrobiotaglioblastoma multiformeamyloidosisSHMT2antioxidantssilicaapoptosisreflux esophagitisgastric ulcerTLC-MSanti-canceranticancerImageJanti-tumordelivery systemwoundHelicobacter pyloridirect protein bindingprotein misfoldingtumor growthdietCrohn's diseasehydrostatic counter-current chromatographyageingrenal cell cancergastric canceramino-acidsSTAT3mechanism of actioninflamm-agingmitophagynecrotizing enterocolitiscell cyclingvitaminsturmeric tubercancertau proteinChemistryBachmeier Beatrice1287693ScCtBLLScCtBLLBOOK9910367753703321Curcumin in Health and Disease3020305UNINA