04031nam 22010093a 450 991036756750332120250203235425.09783039212446303921244310.3390/books978-3-03921-244-6(CKB)4100000010106071(oapen)https://directory.doabooks.org/handle/20.500.12854/48248(ScCtBLL)eb1e8a42-0797-4270-a119-8156881d0cff(OCoLC)1163834607(oapen)doab48248(EXLCZ)99410000001010607120250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierG-quadruplex and MicroorganismsSara N. RichterMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (208 p.)9783039212439 3039212435 G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses' genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms' genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.Medicine and Nursingbicsscbacteriafoldingco-translational refoldingRecQ helicaseregulatory elementconformational dynamicsG4HunterNDPKfluorescencepseudorabies virusEpstein-Barr virus (EBV)structure-activity relationshipPhenDC3eukaryotic hostsHerpesvirustranslation suppressionturn-on ligandsco-transcriptional foldingHerpesviridaeG-quadruplexnucleoside diphosphate kinasenucleic acidsnucleic acids conformationbioinformaticsprotein–DNA interactionaptamersdeinococcusAlphaherpesvirinaeEBNA1G4virushuman papillomavirusesS. cerevisiaegenome stabilityG-quadruplexesmetastable structuregenome evolutionpyridostatinalphaherpesvirusesstructureprotozoagenomeG-quadruplex ligandNMRmicrobesDNAprotein-mRNA interactionsG-quadruplex formationimmediate early promotersMedicine and NursingRichter Sara N1331588ScCtBLLScCtBLLBOOK9910367567503321G-quadruplex and Microorganisms3040468UNINA