03690nam 2200949z- 450 991036756360332120231214132858.03-03921-346-6(CKB)4100000010106110(oapen)https://directory.doabooks.org/handle/20.500.12854/42643(EXLCZ)99410000001010611020202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCancer Metabolomics 2018MDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (184 p.)3-03921-345-8 The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.cell transporterspharmacodynamicscell growthin vitro studymetabolomic signaturesendometabolomelung cancermetabolomicschemometric methodsbladder cancermTORmetabolite profilingmetabolic pathwayshepatocellular carcinomaglutamatesenescence MCF7breath analysisbio activesbiomarkergas chromatography–mass spectrometry (GC–MS)GC-MSlungomicsnutraceuticalsglutaminasemetabolismacylcarnitinesErwinazeKidrolaseglutathionetargeted metabolomicsapoptosisSLC1A5essential amino acidscancer progressionASCT2HR MASalanineanalytical platformsvolatile organic compoundglutaminolysisisotope tracing analysisasparaginasevitamin Ebreast cancerprognosisearly diagnosistocotrienolsNMRprostate cancerin vitrocancerMDA-MB-231Pinto Joanaauth1281247Carvalho MárciaauthDe Pinho Paula GuedesauthBOOK9910367563603321Cancer Metabolomics 20183018420UNINA