04099nam 22006135 450 991035035030332120200705132322.0981-13-8958-610.1007/978-981-13-8958-0(CKB)4100000009451822(DE-He213)978-981-13-8958-0(MiAaPQ)EBC5889016(PPN)260305669(EXLCZ)99410000000945182220190831d2019 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierClinical Epigenetics /edited by Luke B. Hesson, Antonia L. Pritchard1st ed. 2019.Singapore :Springer Singapore :Imprint: Springer,2019.1 online resource (XI, 265 p. 34 illus., 8 illus. in color.)981-13-8957-8 Genetics and epigenetics: a Historical Overview -- The DNA methylation machinery -- Methylcytosine and its oxidised derivatives -- The role of nucleosomes in epigenetic gene regulation -- Circular RNAs in human health and disease -- The role of histone variants in cancer -- DNA methylation and carcinogenesis: Current and future perspectives -- Dysregulation of cis-regulatory elements in cancer -- Germline epigenetic testing of imprinting disorders in a diagnostic setting -- Cancer methylation biomarkers in circulating cell-free DNA -- The clinical utility of epigenetics.In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.Gene expressionMedical geneticsGene therapyCytogeneticsMolecular biologyGene Expressionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12010Gene Functionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12030Gene Therapyhttps://scigraph.springernature.com/ontologies/product-market-codes/B12020Cytogeneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12040Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XGene expression.Medical genetics.Gene therapy.Cytogenetics.Molecular biology.Gene Expression.Gene Function.Gene Therapy.Cytogenetics.Molecular Medicine.611.01816Hesson Luke Bedthttp://id.loc.gov/vocabulary/relators/edtPritchard Antonia Ledthttp://id.loc.gov/vocabulary/relators/edtBOOK9910350350303321Clinical epigenetics1908812UNINA