04085nam 22005655 450 991035032020332120200704221637.0981-13-8906-310.1007/978-981-13-8906-1(CKB)4100000009836957(MiAaPQ)EBC5968658(DE-He213)978-981-13-8906-1(EXLCZ)99410000000983695720191024d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierDrug Discovery in Japan Investigating the Sources of Innovation /edited by Sadao Nagaoka1st ed. 2019.Singapore :Springer Singapore :Imprint: Springer,2019.1 online resource (xv, 333 pages) illustrationsIncludes index.981-13-8905-5 Foreword -- Acknowledgement -- Chapter 1: Introduction -- Chapter 2: Compactin -- Chapter 3: Pravastatin (Pravachol, Mevalotin) -- Chapter 4: Rosuvastatin(Crestor) -- Chapter 5: Leuprorelin (Leuplin, Lupron, Viadur) -- Chapter 6: Oflaxacin and levofloxacin (Tarivid/Cravit) -- Chapter 7: Tamsulosin (Harnal, Flomax, OMNIC) -- Chapter 8: Pranlukast (Onon) -- Chapter 9: Tacrolimus (Prograf) -- Chapter 10: Pioglitazone (Actos, Glustin) -- Chapter 11: Donepezil (Aricept) -- Chapter 12: Candesartan (Blopress, Atacand) -- Chapter 13: Tocilizumab (Actemra,Ro-actemra) -- Chapter 14: Nivolumab (Opdivo) -- Chapter 15: Sources of innovation of drug discovery in Japan and its implications.This book analyzes the drug-discovery process in Japan, based on detailed case studies of 12 groups of 15 innovative drugs. It covers the first statin in the world up to the recent major breakthrough in cancer therapy, the recent immune checkpoint inhibitor, the scientific discovery for which a 2018 Nobel Prize in Physiology or Medicine was awarded to Prof. Tasuku Honjo, Kyoto University. The book shows the pervasive high uncertainty in drug discovery: frequent occurrences of unexpected difficulties, discontinuations, serendipities, and good luck, significantly because drug discovery starts when the underlying science is incomplete. Thus, there exist dynamic interactions between scientific progress and drug discovery. High uncertainty also makes the value of an entrepreneurial scientist high. Such scientists fill the knowledge gaps by absorbing external scientific progress and by relentless pursuit of possibilities through their own research, often including unauthorized research, to overcome crises. Further, high uncertainty and its resolution significantly characterize the evolution of competition in the drug industry. The patent system promotes innovation under high uncertainty not only by enhancing appropriability of R&D investment but also by facilitating the combination of knowledge and capabilities among different firms through disclosure. Understanding such a process significantly benefits the creation of innovation management and policy practices.Economic policyManagementIndustrial managementJapan—HistoryR & D/Technology Policyhttps://scigraph.springernature.com/ontologies/product-market-codes/W43000Innovation/Technology Managementhttps://scigraph.springernature.com/ontologies/product-market-codes/518000History of Japanhttps://scigraph.springernature.com/ontologies/product-market-codes/715020Economic policy.Management.Industrial management.Japan—History.R & D/Technology Policy.Innovation/Technology Management.History of Japan.615.190941Nagaoka Sadaoedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910350320203321Drug Discovery in Japan1939025UNINA