03523nam 22006015 450 991034944310332120200630204152.03-030-31000-010.1007/978-3-030-31000-4(CKB)4100000009374663(DE-He213)978-3-030-31000-4(MiAaPQ)EBC5904652(PPN)248600966(EXLCZ)99410000000937466320190924d2019 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierAdvancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics /by Kevin M. Koo1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (XIII, 102 p.) Springer Theses, Recognizing Outstanding Ph.D. Research,2190-50533-030-30999-1 Unifying Next-Generation Biomarkers and Nanodiagnostic Platforms for Precision Prostate Cancer (PCa) Management -- Colorimetric Gene Fusion Diagnostics for Visual Binary Readout -- Label –Free Surface-Enhanced Raman Scattering Detection System for Clinical Biomarker Targets -- Amplification-Free Electrochemical RNA Biomarker Sensing -- Simultaneous Analysis of Multiple Biomarkers via High-Throughput Parallel Profiling.This book presents a unique concept of merging nanotechnology and novel urinary biomarkers for accurate early prostate cancer detection, discussing an entire progressive pipeline of innovative new strategies in biosensor development, from a simple colorimetric system to a complex system for simultaneous multiple biomarker sensing. For newcomers to the field of nucleic acid biosensing, it also describes various isothermal amplification and amplification-free strategies, which are currently the main research areas. Lastly, the book introduces and demonstrates the notion of clinical nanobiosensor validation toward clinical translation: the ultimate aim of researchers in the biosensor field. This book is a valuable reference resource learners seeking inspiration for cancer biosensor development.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Biomedical engineeringNanotechnologyCancer researchBiomedical Engineering/Biotechnologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B24000Nanotechnologyhttps://scigraph.springernature.com/ontologies/product-market-codes/Z14000Biomedical Engineering and Bioengineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T2700XCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Biomedical engineering.Nanotechnology.Cancer research.Biomedical Engineering/Biotechnology.Nanotechnology.Biomedical Engineering and Bioengineering.Cancer Research.610.28610.28Koo Kevin Mauthttp://id.loc.gov/vocabulary/relators/aut893268MiAaPQMiAaPQMiAaPQBOOK9910349443103321Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics1995456UNINA