04076nam 22006375 450 991034944080332120200630064326.03-030-26780-610.1007/978-3-030-26780-3(CKB)4100000009522889(DE-He213)978-3-030-26780-3(MiAaPQ)EBC5940300(PPN)248604481(EXLCZ)99410000000952288920191010d2019 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierFerroptosis in Health and Disease[electronic resource] /edited by Daolin Tang1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (VI, 324 p. 36 illus., 35 illus. in color.) 3-030-26779-2 Lipid metabolism and ferroptosis -- 2. Iron metabolism and ferroptosis -- 3. Regulation and Function of Autophagy During Ferroptosis -- 4.Heat Shock Proteins: Endogenous Modulators of Ferroptosis -- 5. Biological Aspects of Endoplasmic Reticulum Stress in Ferroptosis -- 6. Gpx4 in ferroptosis -- 7. ACSL4 as the First Reliable Biomarker of Ferroptosis Under Pathophysiological Conditions -- 8. Regulation of Ferroptosis by MicroRNAs -- 9. Ferroptosis in Cardiovascular Disease -- 10. Ferroptosis in Nervous System Diseases -- 11. Regulation of Ferroptosis Through the Cysteine-Glutathione Redox Axis -- 12. Iron-Sulfur Cluster Metabolism Impacts Iron Homeostasis, Ferroptosis Sensitivity, and Human Disease -- 13. Ferroptosis in Liver Disease -- 14. p53 and Ferroptosis -- 15. Ferroptosis in Hemolytic Disorders -- 16. Lipoxygenase in Ferroptosis -- 17. Ferroptosis in Cancer Disease -- 18. Ferroptosis in Cancer Therapy.This book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research. .Cell physiologyApoptosisHuman physiologyProteins Oxidative stressCell Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L33010Apoptosishttps://scigraph.springernature.com/ontologies/product-market-codes/L16060Human Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Protein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Oxidative Stresshttps://scigraph.springernature.com/ontologies/product-market-codes/L16070Cell physiology.Apoptosis.Human physiology.Proteins .Oxidative stress.Cell Physiology.Apoptosis.Human Physiology.Protein Science.Oxidative Stress.571.6Tang Daolinedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910349440803321Ferroptosis in Health and Disease2280555UNINA