03349nam 22005415 450 991034943910332120220309190043.03-030-27480-210.1007/978-3-030-27480-1(CKB)4100000009678253(MiAaPQ)EBC5969426(DE-He213)978-3-030-27480-1(PPN)258860332(EXLCZ)99410000000967825320191031d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierBrain Glycogen Metabolism /edited by Mauro DiNuzzo, Arne Schousboe1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (viii, 443 pages) illustrationsAdvances in Neurobiology,2190-5215 ;233-030-27479-9 1. Introduction or Preface -- 2. Structure and regulation of glycogen synthase in the brain -- 3. Structure and regulation of glycogen phosphorylase in the brain -- 4. Regional distribution of glycogen in the brain -- 5. Metabolism of glycogen in the brain white matter -- 6. Metabolism of glycogen in the brain gray matter -- 7. Contribution of glycogen to brain energy metabolism -- 8. Brain glycogen, compartmentation and ion/transmitter homeostasis -- 9. Role of brain glycogen in learning and memory -- 10. Brain glycogen content and turnover during sleep-wake cycle -- 11. Brain glycogen metabolism in response to exercise -- 12. Brain glycogen metabolism in neuronal excitability and epilepsy -- 13. Brain glycogen metabolism in hypoglycemia and diabetes. .This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease. .Advances in Neurobiology,2190-5215 ;23NeurosciencesNeuroscienceshttps://scigraph.springernature.com/ontologies/product-market-codes/B18006GlicogenthubNeurociènciesthubLlibres electrònicsthubNeurosciences.Neurosciences.GlicogenNeurociències.612.396DiNuzzo Mauroedthttp://id.loc.gov/vocabulary/relators/edtSchousboe Arneedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910349439103321Brain Glycogen Metabolism1995454UNINA