05082nam 22006495 450 991034930780332120200630204250.03-030-28042-X10.1007/978-3-030-28042-0(CKB)4100000008878250(DE-He213)978-3-030-28042-0(MiAaPQ)EBC5922552(PPN)248601431(EXLCZ)99410000000887825020190801d2019 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierHybrid Systems Biology 6th International Workshop, HSB 2019, Prague, Czech Republic, April 6-7, 2019, Revised Selected Papers /edited by Milan Češka, Nicola Paoletti1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (XVI, 181 p. 67 illus., 39 illus. in color.) Lecture Notes in Bioinformatics ;11705Includes index.3-030-28041-1 A multimodular system to study the impact of a focal lesion in neuronal cell cultures -- Reachability analysis and hybrid systems biology - In Memoriam Oded Maler -- Reaction networks, oscillatory motifs and parameter estimation in biochemical systems -- Fixed-point computation of equilibria in biochemical regulatory networks -- Rejection-based simulation of stochastic spreading processes on complex networks -- Controlling noisy expression through auto regulation of burst frequency and protein stability -- Extracting landscape features from single particle trajectories -- A hybrid HMM approach for the dynamics of DNA methylation -- Using a hybrid approach to model central carbon metabolism across the cell cycle -- Data-informed parameter synthesis for population Markov chains-. rPrism - A software for reactive weighted state transition models -- Hybrid modeling of metabolic-regulatory networks.This book constitutes the thoroughly refereed proceedings of the 6th International Workshop on Hybrid Systems Biology, HSB 2019, held in Prague, Czech Republic, in April 2019. The 8 full papers presented in this book together with 1 short paper and 3 invited papers were carefully reviewed and selected from 13 submissions. They cover topics such as: modeling and analysis of metabolic, signaling, and genetic regulatory networks in living cells; models of tissues, organs, physiological models; models and methods coping with incomplete, uncertain and heterogeneous information including learning for biological systems, parametric synthesis and inference; stochastic and hybrid models in biology; hierarchical systems for multi-scale, multi-domain analysis; abstraction, approximation, discretization, and model reduction techniques; modeling, analysis and design for synthetic biology, cyber-biological systems and biomedical studies (e.g. therapies, teleoperation); game-theoretical frameworks and population models in biology (e.g. mixed-effects and Bayesian modeling); biological applications of quantitative and formal analysis techniques (e.g. reachability computation, model checking, abstract interpretation, bifurcation theory, stability and sensitivity analysis); efficient techniques for combined and heterogeneous (stochastic/deterministic, spatial/non-spatial) simulations for biological models; modeling languages and logics for biological systems with related analysis and simulation tools; and control architectures of biological systems including biology-in-the-loop systems and bio-robotics. .Lecture Notes in Bioinformatics ;11705BioinformaticsNumerical analysisMathematical statisticsComputer science—MathematicsComputational Biology/Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/I23050Numeric Computinghttps://scigraph.springernature.com/ontologies/product-market-codes/I1701XProbability and Statistics in Computer Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/I17036Math Applications in Computer Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/I17044Bioinformatics.Numerical analysis.Mathematical statistics.Computer science—Mathematics.Computational Biology/Bioinformatics.Numeric Computing.Probability and Statistics in Computer Science.Math Applications in Computer Science.572.8005.1015113Češka Milanedthttp://id.loc.gov/vocabulary/relators/edtPaoletti Nicolaedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910349307803321Hybrid Systems Biology2518780UNINA