06384nam 2201969z- 450 991034685850332120210211(CKB)4920000000095082(oapen)https://directory.doabooks.org/handle/20.500.12854/40775(oapen)doab40775(EXLCZ)99492000000009508220202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAMP-Activated Protein Kinase SignallingMDPI - Multidisciplinary Digital Publishing Institute20191 online resource (452 p.)3-03897-662-8 Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.Biology, life sciencesbicssc?-linker?RIM2-methoxyestradiol3T3-L1A769662acetyl-CoAactivation loopadaptive thermogenesisadenosine monophosphate-activated protein kinaseadherent junctionsadipocyteadipose tissueAICARAIDAktAMLAMP-activated protein kinaseAMP-activated protein kinase (AMPK)AMPKAMPK kinaseAS160assisted reproduction techniquesatrophyautophagybeigingCaMKK2carriercatechol-<i>O</i>-methyltransferaseCBScellular energy sensingchromatin remodelingCMLCMMLco-expressionCREBdevelopmental origins of health and disease (DOHaD)dietary fatty acidsdifferentiationDNA methylationendothelial cellsendothelial functionendothelial nitric-oxide synthaseenergy deficiencyenergy metabolismenergy utilizationepigeneticsepithelial cellsexercisefatty acid oxidationfiber-typefood intakegestational diabetes mellitusglucose uptakeglycogenglycogen storage diseaseHDAC4/5HDACsheat shock proteinhepatocytehindlimb suspensionhistone modificationhost defensehypertensionhypertrophyhypothalamusIL-1?Immediate early genesindirect calorimetryinfectioninsulin signallingionomycinKATskidney diseaselipid metabolismliverLKB1macrophagesMDCKMDSmechanical unloadingmedulloblastomamembranemembranesmetabolic diseasemetabolic-inflammationmetabolismmicroarraysmitochondriamonocytesmotilitymotor endplate remodelingmTORmycobacteriaMyHC I(?)n/aNAD⁺nectin-afadinNLRP3nutrient-sensing signalsnutrigenomicsnutritionoxidative stressp70S6Kpar complexperoxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?)phenylephrinephosphorylationPKApreeclampsiapregnancyproteasomeprotein acetylationprotein kinase Bprotein synthesispumpregrowthrenin-angiotensin systemresveratrolsignalingsirtuin 1 (SIRT1)skeletal musclesoleus musclesoluble Adenylyl cyclasesonic hedgehogspermatozoasteatosisstresssynaptic activationTAK1TBC1D4tight junctionstranscriptiontransporterULKvasoconstrictionvasodilationZO-1Biology, life sciencesNeumann Dietbertauth1277609Viollet BenoitauthBOOK9910346858503321AMP-Activated Protein Kinase Signalling3011715UNINA