06256nam 2201921z- 450 991034685850332120240429223036.0(CKB)4920000000095082(oapen)https://directory.doabooks.org/handle/20.500.12854/40775(EXLCZ)99492000000009508220202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAMP-Activated Protein Kinase SignallingMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (452 p.)3-03897-662-8 Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.HDACstranscriptionepigeneticsspermatozoapar complexA769662MDCKskeletal muscleAIDphosphorylationenergy metabolismmonocytesautophagyCMLliverhindlimb suspensionpregnancypreeclampsiagestational diabetes mellitusCaMKK2assisted reproduction techniquesnutrient-sensing signalssonic hedgehogprotein acetylationglycogen storage diseaseAMPKadenosine monophosphate-activated protein kinaseAICARindirect calorimetryIL-1?MyHC I(?)HDAC4/5endothelial cellsinfectionhepatocytep70S6Klipid metabolismhost defenseexercisekidney diseaseheat shock protein?RIMmycobacteriaactivation loopdevelopmental origins of health and disease (DOHaD)CREBTAK1metabolic-inflammationphenylephrineAMP-activated protein kinase (AMPK)KATs2-methoxyestradiolDNA methylationNLRP3pump?-linkersteatosisAMPK kinasestressendothelial nitric-oxide synthasevasodilationadherent junctionsepithelial cellsglycogenAktsynaptic activationcellular energy sensingglucose uptaketransporterco-expressionatrophynutrigenomicsmotilityvasoconstrictionfatty acid oxidationoxidative stressAS160membranehistone modificationsirtuin 1 (SIRT1)chromatin remodelinginsulin signallingdietary fatty acidsULKCMMLadaptive thermogenesismTORMDSmechanical unloadingAMLendothelial functionmedulloblastomaPKAadipose tissueNAD⁺membranesnutritionZO-1TBC1D4adipocytesoluble Adenylyl cyclasemetabolismrenin-angiotensin systemenergy utilizationproteasomedifferentiationsignalingperoxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?)hypertrophyAMP-activated protein kinasemetabolic diseaseLKB1soleus musclemacrophagesImmediate early genesCBSbenignmotor endplate remodelingionomycinnectin-afadintight junctionsresveratrolprotein kinase Bregrowthmitochondriaprotein synthesisenergy deficiencycatechol-<i>O</i>-methyltransferasefiber-typemicroarrayscarrieracetyl-CoAhypertension3T3-L1hypothalamusfood intakeNeumann Dietbertauth1277609Viollet BenoitauthBOOK9910346858503321AMP-Activated Protein Kinase Signalling3011715UNINA