05721nam 2201873z- 450 991034684370332120231214133001.03-03921-204-4(CKB)4920000000095203(oapen)https://directory.doabooks.org/handle/20.500.12854/40763(EXLCZ)99492000000009520320202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAmide Bond ActivationMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (466 p.)3-03921-203-6 The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.N-heterocyclic carbenenon planar amideruthenium (Ru)physical organic chemistrygemcitabine prodrugpyramidal amidesbridged sultamscatalysisdipeptidesN-(1-naphthyl)acetamideC-N ? bond cleavagesteric effectspeptide bond cleavagetransition-metal-freepalladiumN-heterocyclic carbenes (NHCs)addition reactionC–O activationrhodiummetal complexescarbanionsthioamidationamide bondintramolecular catalysisantiviral activityadditivity principlepre-catalystsC–N bond cleavagebridged lactamsC–H acidityarynestwisted amidesorganic synthesisaminationSuzuki-Miyauratert-butylcyclopentadienyl complexesC-S formationenzymesDFT studysulfonamide bondNHERON reactionprimaquineentropyamide activationamidationsynthesisamide hydrolysiscarbonylicityamide bond activationamide bond resonanceaminosulfonylationmolecular dynamicsmodel compoundin situamidehomogeneous catalysisheterocyclesanomeric effectmulti-component coupling reactionkineticexcited stateC–H bond cleavagepalladium catalysisamidesthioureaformylationalkynescis/trans isomerizationamide C–N bond activationinteinC-H functionalizationsuccindiamideamide bondscrown etheraminoacylationdirecting groupscytostatic activityreaction thermodynamicsacyl transfertransition metalsN-dimethylformamideDMAcacylative cross-couplingC-H/C-N activationnickel catalysisantibacterial screeningsodiumaryl thioamidesWinkler-Dunitz parameterscatalystN-dimethylacetamidebase-catalyed hydrolysisnitrogen heterocyclescross-couplinginsertionamidicitynitro-aci tautomerismactivationcarbonylationtransamidationaminedistortionPd-catalysisrotational barrier energyhypersensitivityN–C activationmetabolic stability[2+2+2] annulationtwisted amideproteasecyanationamide resonancetrialkylboranecatalystsbiofilm eradicationpharmacokineticspancreatic cancer cellsDMFaryl estersMichael acceptorfumardiamidewater solvationester bond activationcyclizationnuclear magnetic resonancesecondary amidesreaction mechanismdensity functional theorydensity-functional theoryamino acid transportersSzostak Michalauth1302835BOOK9910346843703321Amide Bond Activation3026673UNINA