01548nam a2200361 i 450099100096342970753620020507104500.0970308s1981 ne ||| | eng 0444861580b10154395-39ule_instLE00639847ExLDip.to Fisicaita53(082.2)53.3.153.4.1539.7Course "From nuclei to particles"462113From nuclei to particles = Dai nuclei alle particelle :proceedings of the International School of Physics "Enrico Fermi", Course LXXIX (Varenna on Lake Como, Villa Monastero, 23rd June-5th July 1980) /edited by A. MolinariAmsterdam :North Holland Publ. Co.,1981xii, 532 p. ;24 cm.Proceedings of the International School of Physics "Enrico Fermi" ;79Rendiconti della Scuola Internazionale di Fisica "Enrico Fermi" ;79Nuclear physicsCongressesMolinari, A.Scuola Internazionale di Fisica "Enrico Fermi"International School of Physics "Enrico Fermi"Dai nuclei alle particelle.b1015439517-02-1727-06-02991000963429707536LE006 53(042+082.2) VAR12006000036344le006-E0.00-l- 01010.i1018670027-06-02From nuclei to particles = Dai nuclei alle particelle187929UNISALENTOle00601-01-97ma -engne 0103156nam 2200469z- 450 991034675650332120210211(CKB)4920000000094149(oapen)https://directory.doabooks.org/handle/20.500.12854/49485(oapen)doab49485(EXLCZ)99492000000009414920202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierHIV-Induced Damage of B Cells and Production of HIV Neutralizing AntibodiesFrontiers Media SA20181 online resource (171 p.)Frontiers Research Topics2-88945-461-4 Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists to summarize the current state of knowledge on regulation and development of B cells and antibody responses during HIV-1 infection; fifteen contributions were received comprising both reviews and original articles. The articles are related to B cell dysfunctions identified in HIV-1 infected individuals, production of different types of antibodies (neutralizing versus non neutralizing, and of different isotypes) in vivo during HIV-1 infection and the biological factors which may impact on this process, clinical potential and applications of anti-HIV antibodies and how to achieve neutralizing antibody responses to HIV-1 epitopes upon vaccination. The topic has gathered articles on front-line research undertaken in the field of B cells and antibodies in HIV-1 infection. It is our hope that the collection of articles presented in this book may be useful for new and experienced scholars in the field and add a piece to the complex puzzle of knowledge needed for the development of an HIV-1 vaccine.Medicinebicsscauto-antibodies to CCR5B cellsBAFFclinical potential of HIV-1 antibodiesCXCL13FcRL4Gene ExpressionHIV-1 vaccine targetsmaternal HIV antibodiesmucosal IgA responsesneutralizing and non neutralizing HIV-1 antibodiesMedicineFrancesca Chiodiauth1312840Gabriella ScarlattiauthBOOK9910346756503321HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies3031015UNINA