00857cam2 22002291 450 SOBE0006681020210607085421.020210607d1774 |||||ita|0103 bafreNL1: Tome premierLXXII, 316, [2] p.001SOBE000668082001 Essai philosophique concernant l'entendement humain, ou l'on montre quelle est l'étendue de nos connoissances certaines, & la maniere dont nous y parvenons. Par m. Locke. Traduit de l'anglois par m. Coste1ITBEM20210607RICABEMBEMVI G01004SOBE00066810M 103 Monografia antica SBNWBiblioteca|PrincipessaVI G004-1NO01004DonotcalvanoBEMBEM20210607085315.020210607085421.0tcalvano161339UNISOB02980nam 2200397z- 450 991034675320332120210212(CKB)4920000000094182(oapen)https://directory.doabooks.org/handle/20.500.12854/60393(oapen)doab60393(EXLCZ)99492000000009418220202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierSynaptic Assembly and Neural Circuit DevelopmentFrontiers Media SA20181 online resource (191 p.)Frontiers Research Topics2-88945-630-7 Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the central nervous system critically depends on the establishment of 'precise' synaptic connections between neurons and specific target cells. During synaptogenesis, synapses form, mature, stabilize, and are eliminated through processes that require intimate communication between pre- and postsynaptic partners. The sequential and/or parallel processes dictate the wiring of neural circuits in a rapid and dynamic fashion. Accumulating evidence suggests that activity-dependent synaptic and circuit plasticity reflects the assembly and disassembly of diverse synapses that occur in a distinctive manner in specific neuron types. In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. Clinical implications of this research topic will be considered, emphasizing the importance of these basic neuroscience research activities for translational and therapeutic applications. This includes literature describing recent methodologies for probing key issues regarding assembly/disassembly of synapses and circuits as well as primary research articles that provide critical insights into these fundamental questions in various model systems and experimental preparations.Neurosciencesbicsscneural circuit assemblyNeuronrecognitionsynapseSynaptic adhesion moleculeNeurosciencesJaewon Koauth1279574Chen ZhangauthBOOK9910346753203321Synaptic Assembly and Neural Circuit Development3015635UNINA