02120nam 2200409z- 450 991034675030332120210212(CKB)4920000000094211(oapen)https://directory.doabooks.org/handle/20.500.12854/59417(oapen)doab59417(EXLCZ)99492000000009421120202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierSingle-Domain Antibodies: Biology, Engineering and Emerging ApplicationsFrontiers Media SA20181 online resource (338 p.)Frontiers Research Topics2-88945-432-0 Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.Single-Domain AntibodiesMedicine and Nursingbicsscantibody discoveryantibody engineeringdiagnostic antibodysingle-domain antibodytherapeutic antibodyMedicine and NursingKevin A. Henryauth1279436C. Roger MacKenzieauthBOOK9910346750303321Single-Domain Antibodies: Biology, Engineering and Emerging Applications3015375UNINA