02588oam 2200577I 450 991080018580332120170822114836.00-429-19468-41-4822-9786-810.1201/b17979 (CKB)2670000000560197(EBL)1684509(SSID)ssj0001416960(PQKBManifestationID)11778137(PQKBTitleCode)TC0001416960(PQKBWorkID)11378060(PQKB)10908163(MiAaPQ)EBC1684509(OCoLC)900343699(CaSebORM)9781466561571(EXLCZ)99267000000056019720180331h20152015 uy 0engur|n|---|||||txtccrComputational approaches to protein dynamics from quantum to coarse-grained methods /edited by Monika Fuxreiter1st editionBoca Raton ;London :CRC Press,[2015]©20151 online resource (458 p.)Series in computational biophysicsDescription based upon print version of record.1-4987-0353-4 1-322-62927-7 1-4665-6157-2 Includes bibliographical references and index.section 1. Introduction -- section 2. Enzymatic catalysis : multiscale QM/MM calculations -- section 3. Protein motions : flexibility analysis -- section 4. Approaches to intrinsically disordered proteins -- section 5. Large-scale dynamics -- section 6. Ensemble methods.<P>This groundbreaking work addresses a crucial paradigm shift in structural molecular biology, illustrating how protein dynamics plays a central role in various functions, including enzymatic catalysis, protein-protein interactions, and the organization of complex assemblies. The book presents modern computational techniques for the characterization of proteins and their dynamic properties. The computational methods specifically address the dynamical aspects of protein functionalities, with special emphasis on the analysis of complex assemblies and intrinsically disordered proteins. </P>Series in computational biophysics.Protein engineeringProtein engineering.572/.633Fuxreiter Monika1969-FlBoTFGFlBoTFGBOOK9910800185803321Computational approaches to protein dynamics3874649UNINA03058nam 2200445z- 450 991034674760332120210211(CKB)4920000000094238(oapen)https://directory.doabooks.org/handle/20.500.12854/53853(oapen)doab53853(EXLCZ)99492000000009423820202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular Organization of Membranes: Where Biology Meets BiophysicsFrontiers Media SA20181 online resource (150 p.)Frontiers Research Topics2-88945-409-6 Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and properties define its molecular organisation and, in this way, regulate the function of all associated molecules. Therefore, studying interactions of components, biophysical properties and overall membrane dynamics provides essential information on its function in the context of cell activities. Such knowledge can contribute to biomedical fields such as pharmacology, immunology, neurobiology and many others. The goal of the Research Topic entitled 'Molecular organisation of membranes: where biology meets biophysics' was to provide a comprehensive platform for publishing articles, reviews and opinions focused on membrane organisation and the forces behind its heterogeneous and dynamic structure. We collected 11 works which cover topics as diverse as general membrane organisation models, membrane trafficking and signalling regulation, biogenesis of caveolae, protein-lipid interactions and the importance of membrane-associated tetraspanins networks. The prevalent theme was the existence of membrane nanodomains. To this point, new emerging technologies are presented which own the power to bring a novel insight on how membrane nanodomains are formed and maintained and what is their function. We believe that the collection of works in this Research Topic brings forward some important questions which will stimulate further research in this difficult but exciting field.Molecular Organization of MembranesBiology, life sciencesbicsscCaveolaeCell Membranefluorescence microscopyMembrane propertiesMembrane traffickingNanodomainsSuperresolution microscopyTetraspaninsBiology, life sciencesMarek Cebecauerauth1318741David HolowkaauthBOOK9910346747603321Molecular Organization of Membranes: Where Biology Meets Biophysics3033507UNINA