03959nam 2200421z- 450 991034673770332120210212(CKB)4920000000094337(oapen)https://directory.doabooks.org/handle/20.500.12854/58049(oapen)doab58049(EXLCZ)99492000000009433720202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRegulatory RNAs in the Nervous System, 2nd EditionFrontiers Media SA20181 online resource (346 p.)Frontiers Research Topics2-88945-657-9 Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential.Neurosciencesbicsscagingbrain plasticityneurodegenerationneurodevelopmentneurodevelopmental disordertranscriptomicsNeurosciencesTommaso Pizzorussoauth1326357Laure Bally-CuifauthAlessandro CellerinoauthBOOK9910346737703321Regulatory RNAs in the Nervous System, 2nd Edition3037372UNINA05733nam 22007575 450 991085779080332120250807135549.09783031532337303153233310.1007/978-3-031-53233-7(CKB)32066926600041(MiAaPQ)EBC31361006(Au-PeEL)EBL31361006(DE-He213)978-3-031-53233-7(OCoLC)1457710572(EXLCZ)993206692660004120240513d2024 u| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierJustice and Recovery for Victimised Children Institutional Tensions in Nordic and European Barnahus Models /edited by Susanna Johansson, Kari Stefansen, Elisiv Bakketeig, Anna Kaldal1st ed. 2024.Cham :Springer International Publishing :Imprint: Palgrave Macmillan,2024.1 online resource (294 pages)Palgrave Studies in Victims and Victimology,2947-93639783031532320 3031532325 Chapter 1: Introducing the Barnahus model through the lens of institutional tensions -- Part 1: Legal tensions -- Chapter 2: Criminal law and the Barnahus model -- Chapter 3: Just Outcomes? Exploring Justice Tensions in the Barnahus Model.-Part 2: Organizational tensions -- Chapter 4: What is a Barnahus? Exploring stakeholder views on the Norwegian Barnahus model -- Chapter 5: Bridges or stumbling blocks – factors impacting on the introduction of the Barnahus model in the United Kingdom -- Chapter 6: Dealing with violence, an interpretative, administrative, active or passive approach? External and internal organizational tensions in social services investigative work.-Part 3: Professional and ethical tensions -- Chapter 7: Barnahus work as professional practice: Is standardisation the best way forward? -- Chapter 8: Rights holder, family member or crime victim? Target group constructions in Swedish Barnahus.-Chapter 9: Challenges when investigating crimes against preschool-aged children -- Part 4: Balancing institutional tensions -- Chapter 10: Barnahus in different institutional settings: experiences across Europe -- Chapter 11: Making collaboration work in the field of child abuse and child protection practice: concluding remarks.This open access book contributes to ongoing discussions about how societies should respond to children who have experienced violence and abuse by delving into the Barnahus model: a multidisciplinary and co-located model whose aim is to provide both justice and recovery to victimised children. The promising model was first implemented in the Nordic region and is currently being diffused across Europe, although scientific knowledge about the model remains scarce: the Barnahus model’s potential for delivering holistic services, the various tensions and dilemmas involved in the model, and how dual mandate of Barnahus can be managed all require further research. Continuing from the volume Collaborating Against Child Abuse (2017) which examined the process of Barnahus’ diffusion in the Nordic countries, the current book digs deeper into the intrinsic institutional tensions of the model, as well as those that might arise during collaboration, in order to advance our understanding of what can be achieved through the model and thus improve the situation of child victims of violence and abuse. An institutional perspective is used in the book which is structured in four parts. The first three parts explore different types of institutional tensions –legal, organisational, and professional-ethical, while the fourth focuses on how these tensions may be balanced. The book’s authors chart this new phase in the diffusion and translation of the Barnahus model. Their analyses will provide valuable guidance to countries that are currently considering or are already implementing the model. Susanna Johansson is an associate professor at the School of Social Work, Lund University, Sweden. Kari Stefansen is a research professor at Norwegian Social Research (NOVA) at Oslo Metropolitan University, Norway. Elisiv Bakketeig is a research professor at Norwegian Social Research (NOVA) at Oslo Metropolitan University, Norway. Anna Kaldal is a professor in procedural law at the Law Faculty of Stockholm University, Sweden. .Palgrave Studies in Victims and Victimology,2947-9363Juvenile delinquentsVictims of crimesCriminal behaviorSocial serviceFamily policyYouth Offending and Juvenile JusticeVictimologyCriminal BehaviorSocial WorkChildren, Youth and Family PolicyChildren and Youth WorkJuvenile delinquents.Victims of crimes.Criminal behavior.Social service.Family policy.Youth Offending and Juvenile Justice.Victimology.Criminal Behavior.Social Work.Children, Youth and Family Policy.Children and Youth Work.364.36Johansson Susanna1980-aut1765411Stefansen Kari1971-autBakketeig Elisiv1966-autKaldal AnnaautMiAaPQMiAaPQMiAaPQBOOK9910857790803321Justice and Recovery for Victimised Children4207067UNINA