02281nam 2200493 450 991034673270332120231027212101.01-83962-200-81-83962-199-0(CKB)4920000000094383(NjHacI)994920000000094383(oapen)https://directory.doabooks.org/handle/20.500.12854/40610(MiAaPQ)EBC30390279(Au-PeEL)EBL30390279(EXLCZ)99492000000009438320221017d2019 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierAldosterone-Mineralocorticoid Receptor Cell Biology to Translational Medicine /Brian Harvey, Frederic Jaisser, editors1st ed.IntechOpen2019London :IntechOpen,[2019]©20191 online resource (300 pages) illustrations1-83962-198-2 Includes bibliographical references and index.This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.AldosteronePhysiological effectMedicineEndocrinologyHealth SciencesAldosteronePhysiological effect.615.364Harvey BrianJaisser FredericNjHacINjHaclBOOK9910346732703321Aldosterone-Mineralocorticoid Receptor3386093UNINA