04204nam 22010453a 450 991034668930332120250203235432.09783038978954303897895710.3390/books978-3-03897-895-4(CKB)4920000000094776(oapen)https://directory.doabooks.org/handle/20.500.12854/59479(ScCtBLL)65f04698-4784-46f2-9644-efe58e35a742(OCoLC)1117887350(oapen)doab59479(EXLCZ)99492000000009477620250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierSmart Nanovesicles for Drug Targeting and DeliveryCarlotta Marianecci, Maria CarafaMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (198 p.)9783038978947 3038978949 Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action. The drug/contrast agent-containing vesicles need to be directed to precise locations within the body to obtain desired magnitude and duration of the therapeutic or diagnostic effect. This spatial control in the delivery might open new avenues to modulate drug activity while avoiding side-effects and to optimize contrast agent properties while avoiding a broad distribution in the organism. However, delivering and targeting active substances into specific tissues and cells is still a challenge in designing novel therapeutic approaches against untreatable disorders, such as tumors and degenerative diseases.Medicine and Nursingbicsscprotein coronabuspironedrug deliveryPlectranthus eckloniiantiproliferative activitypancreatic ductal adenocarcinomatetraethyl orthosilicatecancer therapynanoparticlescationic liposomesIbuprofenSBA-15gastrointestinal stabilitymesoporous silica nanoparticlesParvifloron Danti-tumor drugsliposomesgingiva mesenchymal stromal cellssoy lecithin liposomesMCM-41lipophilic compoundmultifunctional liposomescaryophyllene sesquiterpenedrug loadinglamellarityhCMEC/D3 cellsgold shellmagnetic/plasmonic nanoparticlespH-sensitive niosomeshot flushesnasal delivery systemandrographolidebrain deliverypancreatic cancerPainexosomesNSAIDsfreeze-dryingmanganese ferritesurfactantcytotoxicitypaclitaxelovariectomized ratPAMPAuptake and safetynanovesicular nasal carrierStober's synthesisAnalgesiaprotocellsnanocochleatessquamous cell carcinomaMedicine and NursingMarianecci Carlotta1302831Carafa MariaScCtBLLScCtBLLBOOK9910346689303321Smart Nanovesicles for Drug Targeting and Delivery3026667UNINA