00963nam a2200265 i 450099100119051970753620020507112644.0970308s1976 uk ||| | eng b10186256-39ule_instLE00643654ExLDip.to Fisicaita53.9.788RA1231International Commission on Radiological Protection298334Protection against ionizing radiation from external sources /ICRPOxford :Pergamon,19761 v. :ill. ;25 cm.RadiationRadiation protection.b1018625621-09-0627-06-02991001190519707536LE006 53.9.7 ICR12006000056243le006-E0.00-l- 00000.i1022902427-06-02Protection against ionizing radiation from external sources190277UNISALENTOle00601-01-97ma -enguk 0103444nam 22009013a 450 991034667960332120250203235434.09783038979357303897935X10.3390/books978-3-03897-935-7(CKB)4920000000094871(oapen)https://directory.doabooks.org/handle/20.500.12854/56030(ScCtBLL)3d38fb3f-8d5a-47ab-86f4-c2f83d44618b(OCoLC)1117907930(oapen)doab56030(EXLCZ)99492000000009487120250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierPeroxiredoxin 6 as a Unique Member of the Peroxiredoxin FamilyAron B. FisherMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (152 p.)9783038979340 3038979341 The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.MedicinebicsscNADPH (nicotinamide adenine dinucleotide phosphate) oxidasesperm capacitationphospholipid hydroperoxidecorneaperoxidasephospholipase A21-Cys Prdxknock-in mousedrug deliveryantioxidant activitysulfinic acidradioprotectionspermatozoaperoxiredoxin 6mass spectroscopic analysisknockout mousephospholipase A2 activityliposomesmitochondrial membrane potentiallipid peroxidationPLA2 activityionizing radiationglutathione peroxidasePeroxiredoxinPrdx6 structuremembrane repairsubstrate bindinginflammationreactive oxygen speciesPrdx6sulfonic/sulfinic acidFuchs' endothelial corneal dystrophyendotheliumfertilizationperoxidatic cysteinethioredoxin foldredox balancesurfactant protein Adiabetesoxidative stressMedicineFisher Aron B1331910ScCtBLLScCtBLLBOOK9910346679603321Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family3040640UNINA