04335nam 2201141z- 450 991034666480332120231214133547.03-03897-917-1(CKB)4920000000095019(oapen)https://directory.doabooks.org/handle/20.500.12854/45509(EXLCZ)99492000000009501920202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDrug metabolism, pharmacokinetics and bioanalysis /special issue editors, Hye Suk Lee, Kwang-Hyeon LiuMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (230 p.)3-03897-916-3 Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.DrugsMetabolismhuman liver microsomesalcohol addictionUGTultra-high-pressure liquid chromatographyadalimumabprocainamideLC-MS/MSDA-9805paeonolLC-QTOF-MS/MSYRA-1909chlorogenic acidimmunoprecipitationEurycoma longifoliaCYPcaffeic acidratpharmaceutical excipientKorean red ginseng extractStauntonia hexaphylla leaf extractbioanalysisHPLC-MS/MSB6eurycomanonebioavailabilitydrying technologyGB3diclofenac129-Glatm1Kul/Jaglyconecaffeic acid O-glucuronidesorganic anion transporting polypeptideprotein precipitationmetabolic stabilityFabry diseasebiopharmaceuticalsimperatorinneochlorogenic acidgastric ulcersaikosaponin ahairanthraquinoneacetyl tributyl citratepharmacokineticsbrain distributionmematineethyl glucuronidepharmacokineticloxoprofenliquid chromatography-quadrupole TOF MSglucuronidationesomeprazolemetformincytochrome P450glycosideAUDIT scoreprotein stabilityefficacyLC-HR/MScryptochlorogenic acidaceclofenacdrug interactionliquid chromatography-tandem mass spectrometryOsthenolplasmaN-acetylprocainamidediabetesDrugsMetabolism.615.1Lee Hye Suk(Pharmacist),Liu Kwang-HyeonBOOK9910346664803321Drug Metabolism, Pharmacokinetics and Bioanalysis3020262UNINA