06729nam 2202017z- 450 991034666110332120210211(CKB)4920000000095056(oapen)https://directory.doabooks.org/handle/20.500.12854/54549(oapen)doab54549(EXLCZ)99492000000009505620202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Advances on Zika Virus ResearchMDPI - Multidisciplinary Digital Publishing Institute20191 online resource (552 p.)3-03897-764-0 Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders-including fetal microcephaly and Guillain-Barré syndrome in adults-have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus-host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.Medicine and NursingbicsscAedes aegyptiAfrican-lineageanti-viral immunityantiviralantiviral compoundsantiviral responsesantiviralsapoptosisarbovirusAsian lineageAsian-lineageassay standardizationastrocytomasbacterial artificial chromosomeBacterial artificial chromosomeBayesian analysesblood-retinal barrierboolean logic-processing nucleic acid probescell surface receptorschimeric virusesclinical trialscongenital Zika syndromecross-reactionscryptic promoter silencingcytopathic effectsdengue virusdengue virusesdetoxification and immune system responsesdiagnosisdsRNAeIF4AELISAemerging arbovirusEQAexternal quality assessmenteyefetal infectionflavivirusflavivirusesFSS13025Full-length cDNA infectious clonesfull-length molecular clonegene expressiongenetic variabilityheme-oxygenase 1hepatocyteshost genetic variationhost-directed antiviralshuman brain glial cellsIgAIgG avidity testsimmune responseindirect immunofluorescenceinfectioninfectious cDNAinfectious cloneinfectious RNAinnate responseinsecticide resistanceisothermal nucleic acid amplificationlaboratory preparednessmicrocephalymicroglia cellsmicroRNAsmicrosphere immunoassaymolecular diagnosticsmonoclonal antibodiesmosquitomosquito surveillancemosquito-borne flavivirusMR766multiplex nucleic acid detectionmutagenesisnatural historyneural cellsneural progenitor cellsneuroinflammationneuronsneuropathogenesisNHPNon-human primatesNS1 proteinNS2A proteinNS5nucleic acid computationnucleic acid strand exchangeocularoptimisedoutbreak controlplacenta cellsplaque reduction neutralization testplasmid toxicitypoint-of-care diagnosticspolymerase chain reactionpregnancyprM-E proteinsprostateQCMDreplicationrepliconreporter virusresearch models and toolsreverse geneticsrhesus macaquesRNA-seqsecondary infectionsserologysexual transmissionsilvestrolsiRNAsubgenomic replicontestestesticular cellstestisTet-inducibletherapeuticstherapyTLR7/8type I IFN antagonistvaccinesvalidatedviral counteractionviral evolutionviral fitnessviral genetic variationviral pathogenesisviral pathogenicityviral permissivenessviral persistenceviral replicationviral survivalvirus attachmentvirus like particlesZikazika virusZika virusZika virus (ZIKV)Ziks virusZIKVZIKV-associated neurologic disordersZIKV-host interactionsMedicine and NursingMartinez-Sobrido Luisauth1311265Almazan Toral FernandoauthBOOK9910346661103321New Advances on Zika Virus Research3030072UNINA