06637nam 2201981z- 450 991034666110332120231214133555.0(CKB)4920000000095056(oapen)https://directory.doabooks.org/handle/20.500.12854/54549(EXLCZ)99492000000009505620202102d2019 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Advances on Zika Virus ResearchMDPI - Multidisciplinary Digital Publishing Institute20191 electronic resource (552 p.)3-03897-764-0 Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.microRNAsantiviralsreverse geneticsnucleic acid computationviral pathogenesisplaque reduction neutralization testclinical trialsviral genetic variationviral fitnesspregnancytype I IFN antagonistprM-E proteinseyerepliconantiviral responsesBacterial artificial chromosomegene expressionNS1 proteinviral permissivenessZIKV–host interactionsreporter virusviral persistenceblood-retinal barriervirus like particlesemerging arbovirusNon-human primatesheme-oxygenase 1mosquito surveillanceantiviral compoundsZIKV-associated neurologic disordersexternal quality assessmentoutbreak controltherapeuticscryptic promoter silencingtestisneuronsmutagenesisRNA-seqmicrosphere immunoassayhost-directed antiviralsmolecular diagnosticsBayesian analysesastrocytomasFull-length cDNA infectious clonesviral pathogenicityneural progenitor cellsfull-length molecular cloneantiviralmultiplex nucleic acid detectionAsian-lineagenucleic acid strand exchangeIgAAfrican-lineagevaccinesZikaresearch models and toolsimmune responseIgG avidity testspolymerase chain reactionAsian lineagesexual transmissionTLR7/8neuropathogenesiscross-reactionsgenetic variabilitymosquitoZIKVinfectious cDNAprostatehost genetic variationmonoclonal antibodiesoptimisedanti-viral immunityQCMDarbovirusFSS13025MR766NS5EQAtesticular cellsvirus attachmentflavivirusmosquito-borne flavivirusdsRNAboolean logic-processing nucleic acid probesZiks virusviral replicationAedes aegyptiinfectionnatural historyinfectious RNAzika viruschimeric virusessubgenomic repliconreplicationhuman brain glial cellsmicroglia cellshepatocytesbacterial artificial chromosomedetoxification and immune system responsestestesdengue virusesZika virusinsecticide resistanceNS2A proteinplasmid toxicitycell surface receptorsserologyviral evolutionlaboratory preparednessflavivirusesTet-inducibledengue virusdiagnosisassay standardizationinfectious cloneELISAinnate responsecongenital Zika syndromesecondary infectionsapoptosisviral survivalocularvalidatedrhesus macaquesneuroinflammationplacenta cellsNHPZika virus (ZIKV)point-of-care diagnosticsisothermal nucleic acid amplificationmicrocephalycytopathic effectsindirect immunofluorescencefetal infectiontherapysiRNAviral counteractionneural cellssilvestroleIF4AMartinez-Sobrido Luisauth1311265Almazan Toral FernandoauthBOOK9910346661103321New Advances on Zika Virus Research3030072UNINA