04206nam 22005535 450 991033794710332120200702145532.03-030-16624-410.1007/978-3-030-16624-3(CKB)4100000008347180(MiAaPQ)EBC5785811(DE-He213)978-3-030-16624-3(PPN)238492893(EXLCZ)99410000000834718020190604d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierCancer Stem Cell Resistance to Targeted Therapy[electronic resource] /edited by Cristina Maccalli, Matilde Todaro, Soldano Ferrone1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (267 pages)Resistance to Targeted Anti-Cancer Therapeutics,2196-5501 ;193-030-16623-6 Cancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index.This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.Resistance to Targeted Anti-Cancer Therapeutics,2196-5501 ;19Cancer researchImmunologyMolecular biologyCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Immunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XCancer research.Immunology.Molecular biology.Cancer Research.Immunology.Molecular Medicine.616.994061Maccalli Cristinaedthttp://id.loc.gov/vocabulary/relators/edtTodaro Matildeedthttp://id.loc.gov/vocabulary/relators/edtFerrone Soldanoedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910337947103321Cancer Stem Cell Resistance to Targeted Therapy1945690UNINA