03147nam 22005175 450 991033753160332120200702025733.097830301783149783030178321 (e-book)10.1007/978-3-030-17832-1(CKB)4100000008525451(DE-He213)978-3-030-17832-1(MiAaPQ)EBC5799417(PPN)258860014(EXLCZ)99410000000852545120190626d2019 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierTargeted Therapies for Lung Cancer /edited by Ravi Salgia1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (IX, 238 p. 19 illus. in color.) Current Cancer Research,2199-25843-030-17832-3 3-030-17831-5 1. EGFR -- 2. ALK -- 3. ROS1 -- 4. B-RAF -- 5. MET -- 6. HER2 -- 7. NTRK -- 8. SCLC -- 9. Complexities of the Lung Tumor Microenvironment -- 10. KRAS -- 11. Targeting Epigenetic Regulators in Cancer to Overcome Targeted Therapy Resistance.This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.Current Cancer Research,2199-2584Cancer researchMolecular biologyCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XCancer research.Molecular biology.Cancer Research.Molecular Medicine.614.5999616.9942406Salgia Raviedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910337531603321Targeted Therapies for Lung Cancer1736805UNINA