02017nam 2200373 450 991031772470332120231214145438.0953-51-7220-4(CKB)4970000000098837(iGPub)INOP0002091(oapen)https://directory.doabooks.org/handle/20.500.12854/66660(EXLCZ)99497000000009883720200130014 xx c0 0engurcn#|||m|||atxtrdacontentcrdamediacrrdacarrierAdult stem cell nichesIntechOpen2014[Place of publication not identified] :IntechOpen,2014.©20141 online resource (332 pages)953-51-1718-1 Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.SCIENCE / Life Sciences / Cell BiologybisacshCellular biology (cytology)SCIENCE / Life Sciences / Cell Biology.Wislet-Gendebien Sabineedt1295061Wislet-Gendebien SabineBOOK9910317724703321Adult stem cell niches3023350UNINA