02252nam 2200421 450 991031761320332120230718231847.0953-51-6935-1(CKB)4970000000097952(NjHacI)994970000000097952(oapen)https://directory.doabooks.org/handle/20.500.12854/65888(EXLCZ)99497000000009795220221020d2012 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierPancreatic Cancer Molecular Mechanism and Targets /edited by Sanjay K. SrivastavaIntechOpen2012[Place of publication not identified] :IntechOpen,2012.1 online resource (446 pages)953-51-0410-1 Includes bibliographical references and index.This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-fluorouracil.Pancreatic CancerOncologyOncologyOncology.616.994Srivastava Sanjay Kedt1370249Srivastava Sanjay K.NjHacINjHaclBOOK9910317613203321Pancreatic Cancer3397913UNINA