05314nam 2200697Ia 450 991102002170332120200520144314.09786610520527978128052052512805205239783527605439352760543697835276023843527602380(CKB)1000000000019330(EBL)482326(OCoLC)64625120(SSID)ssj0000149055(PQKBManifestationID)11136657(PQKBTitleCode)TC0000149055(PQKBWorkID)10237987(PQKB)11596085(MiAaPQ)EBC482326(Perlego)2759132(EXLCZ)99100000000001933020040601d2004 uy 0engur|n|---|||||txtccrErythropoietin blood, brain and beyond /Arthur J. SytkowskiWeinheim Wiley-VCH20041 online resource (240 p.)Description based upon print version of record.9783527304950 3527304959 Includes bibliographical references and index.Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein?3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways6.2.1 Phosphorylation of the Erythropoietin ReceptorThe use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The booErythropoietinErythropoietinPhysiological effectErythropoietinTherapeutic useErythropoietin.ErythropoietinPhysiological effect.ErythropoietinTherapeutic use.612.111615.39Sytkowski Arthur J1838478MiAaPQMiAaPQMiAaPQBOOK9911020021703321Erythropoietin4417454UNINA03932nam 22005055 450 991030343230332120200705061012.03-030-01869-510.1007/978-3-030-01869-6(CKB)4100000007223514(MiAaPQ)EBC5621027(DE-He213)978-3-030-01869-6(EXLCZ)99410000000722351420181217d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierConsilience, Truth and the Mind of God Science, Philosophy and Theology in the Search for Ultimate Meaning /by Richard J. Di Rocco1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (163 pages)3-030-01868-7 Chapter1. Introduction: The Search for Ultimate Meaning (R.J. Di Rocco) -- Chapter2. The Polarization and Reconciliation of Science and Religion(R.J. Di Rocco) -- Chapter3. Physics (R.J. Di Rocco) -- Chapter4. Cosmogenesis (R.J. Di Rocco) -- Chapter5. Abiogenesis: The Origin of Life (R.J. Di Rocco and E. E. Coons) -- Chapter6. Paleopsychology: The Emergence of Mind in the Universe (R.J. Di Rocco and E. E. Coons) -- Chapter7. Mind Knowing Truth (R.J. Di Rocco) -- Chapter8. Consilient Truth and the Mind of God: A Synthesis (R.J. Di Rocco and A.J. Kyriazis) -- Chapter9. Man in Search of God: The Ecstasy of Prophets (R.J. Di Rocco) -- Chapter10. God in Search of Man: The Terror of Prophets (R.J. Di Rocco).This book argues that God can be found within the edifice of the scientific understanding of physics, cosmology, biology and philosophy. It is a rewarding read that asks the Big Questions which humans have pondered since the dawn of the modern human mind, including: Why and how does the universe exist? From where do the laws of physics come? How did life and mind arise from inanimate matter on Earth? Science and religion have a common interest in the answers to such questions, yet many scientists and believers have been at odds for centuries. The author and contributors present a program for moving beyond the vastly different perspectives of reality offered by science and religion. Historical proofs for the existence of God are considered in light of the possibility that the universe may be only one in an eternal multiverse that contains an infinite number of other universes. Readers will find a modification of St. Augustine’s Argument from Truth for the existence of the necessary, self-sufficient being commonly referred to as God. This book is suited to all with an interest in the crossing points of science and religion, providing much food for thought and reflection. If in the end, you cannot accede to philosophy’s proofs, or theism’s invitation to faith, perhaps you will nevertheless say ‘yes’ to the amazing universe in which we live.Religion—PhilosophyPsychology and religionEvolution (Biology)Philosophy of Religionhttps://scigraph.springernature.com/ontologies/product-market-codes/E33000Religion and Psychologyhttps://scigraph.springernature.com/ontologies/product-market-codes/Y46000Evolutionary Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L21001Religion—Philosophy.Psychology and religion.Evolution (Biology)Philosophy of Religion.Religion and Psychology.Evolutionary Biology.215261.55Di Rocco Richard Jauthttp://id.loc.gov/vocabulary/relators/aut932906BOOK9910303432303321Consilience, Truth and the Mind of God2099744UNINA